Highly promising antitumor agent of a novel Platinum(II) complex bearing a tetradentate chelating ligand

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridRemzi Okan Akar / 0000-0001-8687-2034
dc.authoridMerve Erkısa Genel / 0000-0002-3127-742X
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidRemzi Okan Akar / 57210603359
dc.authorscopusidSelin Selvi / 57210599688
dc.authorscopusidMerve Erkısa Genel / 57126208900
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.authorwosidRemzi Okan Akar / AAF-4576-2019
dc.authorwosidSelin Selvi / FZU-0996-2022
dc.authorwosidMerve Erkısa Genel / AAM-1001-2020
dc.contributor.authorYılmaz, İsmail
dc.contributor.authorAkar, Remzi Okan
dc.contributor.authorErkısa Genel, Merve
dc.contributor.authorSelvi, Selin
dc.contributor.authorŞengül, Abdurrahman
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2020-08-30T20:06:11Z
dc.date.available2020-08-30T20:06:11Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Rektörlüken_US
dc.descriptionYILMAZ, ismail/0000-0002-0139-0122; Erkisa, Merve/0000-0002-3127-742X; Ulukaya, Engin/0000-0003-4875-5472; AKAR, Okan/0000-0001-8687-2034en_US
dc.descriptionAkar, Okan Remzi ; Erkisa Genel, Merve ; Selvi, Selin ; Ulukaya, Engin (isu author)en_US
dc.description.abstractA new mononuclear cationic platinum(II) coordination compound with 6,6'-bis(NH-benzimidazol-2-yl)-2,2'-bipyridine (L) ligand having N-4-tetradentate binding pocket [Pt(L)]-Cl-2.2H(2)O (Complex 1) was synthesized and characterized by FTIR(ATR), UV-vis, H-1 NMR, APCI and MALDI MS, and CHN analysis. The antigrowth effect of Complex 1 was tested in breast cancer (MDA-MB-231), lung cancer (A549), colorectal cancer (HCT-116), prostate cancer (PC-3) cell lines, and bronchial epithelial cell line (BEAS-2B) by the SRB and ATP cell viability assays. Apoptosis was detected with Annexin V, mitopotential, BCL-2 inactivation, and gamma H2AX assays by flow cytometry. Complex 1 was found to have cytotoxic activity of MDA-MB-231, A549, HCT-116, and PC-3 cancer cell lines in a dose-dependent manner for 48 h. Complex 1 has been found to cause cell death through different mechanisms depending on the type of cancer. The findings indicated that complex induced intrinsic apoptosis with the increased mitochondrial membrane depolarization level, Bcl-2 inactivation, and DNA damage in PC-3 and A549 cell lines.en_US
dc.description.sponsorshipTurkish Scientific and Technical Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [TBAG-2450(104T060)]en_US
dc.description.sponsorshipThis work was partly supported by the Turkish Scientific and Technical Research Council (TUBITAK) [grant number TBAG-2450(104T060)].en_US
dc.identifier.citationYilmaz, I., Akar, O. R., Erkisa, M., Selvi, S., Sengul, A., & Ulukaya, E. (2020). Highly Promising Antitumor Agent of a Novel Platinum(II) Complex Bearing a Tetradentate Chelating Ligand. ACS MEDICINAL CHEMISTRY LETTERS, 11(5), 940–948. https://doi.org/10.1021/acsmedchemlett.9b00676en_US
dc.identifier.doi10.1021/acsmedchemlett.9b00676en_US
dc.identifier.endpage948en_US
dc.identifier.issn1948-5875en_US
dc.identifier.issue5en_US
dc.identifier.pmid32435409en_US
dc.identifier.scopus2-s2.0-85082528330en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage940en_US
dc.identifier.urihttps://doi.org/10.1021/acsmedchemlett.9b00676
dc.identifier.urihttps://hdl.handle.net/20.500.12713/409
dc.identifier.volume11en_US
dc.identifier.wosWOS:000535281200051en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAkar, Remzi Okanen_US
dc.institutionauthorErkısa Genel, Merveen_US
dc.institutionauthorSelvi, Selinen_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherAmer Chemical Socen_US
dc.relation.ispartofAcs Medicinal Chemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlatinumen_US
dc.subjectN-4-Donor Liganden_US
dc.subjectBenzimidazoleen_US
dc.subjectPyridineen_US
dc.subjectCytotoxicityen_US
dc.subjectApoptosisen_US
dc.titleHighly promising antitumor agent of a novel Platinum(II) complex bearing a tetradentate chelating liganden_US
dc.typeArticleen_US

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