Worth of pan-immune-inflammation value in trismus prediction after concurrent chemoradiotherapy for nasopharyngeal carcinomas

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dc.authoridselek, ugur/0000-0001-8087-3140
dc.authoridTopkan, Erkan/0000-0001-8120-7123
dc.authoridYilmaz, Busra/0000-0003-0633-5648
dc.authoridSomay, efsun/0000-0001-8251-6913
dc.authoridOzturk, Duriye/0000-0002-3265-2797
dc.authorwosidselek, ugur/O-5474-2014
dc.authorwosidTopkan, Erkan/AAG-2213-2021
dc.contributor.authorSomay, Efsun
dc.contributor.authorYilmaz, Busra
dc.contributor.authorTopkan, Erkan
dc.contributor.authorOzdemir, Beyza Sirin
dc.contributor.authorOzturk, Duriye
dc.contributor.authorBesen, Ali Ayberk
dc.contributor.authorMertsoylu, Huseyin
dc.date.accessioned2024-05-19T14:46:24Z
dc.date.available2024-05-19T14:46:24Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: Radiation-induced trismus (RIT), one of the rare but serious side effects of concurrent chemoradiotherapy (C-CRT), is difficult to predict with high accuracy. We aimed to examine whether the pretreatment pan-immune-inflammation value (PIV) measures predict RIT in patients with locally advanced nasopharyngeal carcinoma (LA-NPC) receiving C-CRT.Methods: Data of patients with LA-NPC who underwent C-CRT and had maximum mouth openings (MMO) > 35 mm were reviewed. Any MMO of 35 mm or less after C-CRT was considered RIT. All PIV values were computed using the complete blood count test results: PIV = (Platelets x Monocytes x Neutrophils) divided by Lymphocytes. The receiver operating characteristic analysis was employed to dissect a possible association between pre-treatment PIV readings and RIT status. Confounding variables were tested for their independent relationship with the RIT rates using logistic regression analysis.Results: The research comprised 223 participants, and RIT was diagnosed in 46 (20.6%) at a median time from C-CRT to RIT of 10 months (range: 5-18 months). Pre-C-CRT PIV levels and RIT rates were analyzed using receiver operating characteristic curve analysis, with 830 being the optimal cutoff (area under the curve: 92.1%; sensitivity: 87.5%; specificity: 85.5%; Youden index: 0.730). RIT was significantly more prevalent in the PIV > 830 cohort than its PIV <= 830 counterpart (60.3% vs. 5%; hazard ratio 5.79; P < 0.001). Multivariate logistic regression analysis revealed that advanced T-stage (P = 0.004), masticatory apparatus dose V58Gy >=%32 (P = 0.003), and PIV > 830 (P < 0.001) were independently linked with significantly elevated rates of RIT.Conclusion: The presence of elevated pre-C-CRT PIV is a unique biological marker that independently predicts increased RIT rates in LA-NPC undergoing C-CRT.en_US
dc.identifier.doi10.1177/03936155231223198
dc.identifier.endpage88en_US
dc.identifier.issn0393-6155
dc.identifier.issn1724-6008
dc.identifier.issue1en_US
dc.identifier.pmid38192114en_US
dc.identifier.scopus2-s2.0-85181668081en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage80en_US
dc.identifier.urihttps://doi.org10.1177/03936155231223198
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5513
dc.identifier.volume39en_US
dc.identifier.wosWOS:001140065900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofInternational Journal of Biological Markersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectRadiation-Induced Trismusen_US
dc.subjectPan-Immune-Inflammation Valueen_US
dc.subjectConcurrent Chemoradiotherapyen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.titleWorth of pan-immune-inflammation value in trismus prediction after concurrent chemoradiotherapy for nasopharyngeal carcinomasen_US
dc.typeArticleen_US

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