Raman tweezers as an alternative diagnostic tool for paroxysmal nocturnal hemoglobinuria

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dc.authoridŞeyma Parlatan / 0000-0003-2355-4674en_US
dc.authorscopusidŞeyma Parlatan / 57267804700
dc.authorwosidŞeyma Parlatan / ABF-3308-2020en_US
dc.contributor.authorSoysal, Kaan Batu
dc.contributor.authorParlatan, Şeyma
dc.contributor.authorMastanzade, Metban
dc.contributor.authorÖzbalak, Murat
dc.contributor.authorYenerel, Mustafa Nuri
dc.contributor.authorÜnlü, Mehmet Burçin
dc.contributor.authorBaşar, Günay
dc.contributor.authorParlatan, Uğur
dc.date.accessioned2021-09-01T06:39:56Z
dc.date.available2021-09-01T06:39:56Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Radyoterapi Bölümüen_US
dc.description.abstractParoxysmal nocturnal hemoglobinuria (PNH) is a rare disease characterized by hemolysis of red blood cells (RBC) and venous thrombosis. The gold standard method for the diagnosis of this disease is flow cytometry. Here, we propose a combined optical tweezers and Raman spectral (Raman tweezers) approach to analyze blood samples from volunteers with or without PNH conditions. Raman spectroscopy is a well-known method for investigating a material's chemical structure and is also used in molecular analysis of biological compounds. In this study, we trap individual RBCs found in whole blood samples drawn from PNH patients and the control group. Evaluation of the Raman spectra of these cells by band component analysis and machine learning shows a significant difference between the two groups. The specificity and the sensitivity of the training performed by support vector machine (SVM) analysis were found to be 81.8% and 78.3%, respectively. This study shows that an immediate and high accuracy test result is possible for PNH disease by employing Raman tweezers and machine learning.en_US
dc.identifier.citationSoysal, K. B., Parlatan, S., Mastanzade, M., Ozbalak, M., Yenerel, M. N., Basar, G., ... & Parlatan, U. (2021). Raman tweezers as an alternative diagnostic tool for paroxysmal nocturnal hemoglobinuria. Analytical Methods.en_US
dc.identifier.doi10.1039/d1ay01116ben_US
dc.identifier.issn1759-9660en_US
dc.identifier.pmid34409854en_US
dc.identifier.scopus2-s2.0-85115426399en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://www.doi.org/10.1039/d1ay01116b
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2014
dc.identifier.wosWOS:000686230400001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorParlatan, Şeyma
dc.language.isoenen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleRaman tweezers as an alternative diagnostic tool for paroxysmal nocturnal hemoglobinuriaen_US
dc.typeArticleen_US

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