Effect of the MiR-99b and MiR-135b on peritoneal carcinomatosis and liver metastasis in colorectal cancer

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dc.authoridGuney Eskiler, Gamze/0000-0002-2088-9914
dc.authoridKOCER, Havva Belma/0000-0002-9888-0661
dc.authoridAziret, Mehmet/0000-0001-6758-7289
dc.authorwosidGuney Eskiler, Gamze/AAB-6011-2022
dc.authorwosidKOCER, Havva Belma/IXN-8658-2023
dc.authorwosidAziret, Mehmet/I-5483-2014
dc.contributor.authorAziret, Mehmet
dc.contributor.authorEskiler, Gamze Guney
dc.contributor.authorCakar, Gozde Cakirsoy
dc.contributor.authorOzkan, Asuman Deveci
dc.contributor.authorErcan, Metin
dc.contributor.authorBilir, Cemil
dc.contributor.authorPolat, Erdal
dc.date.accessioned2024-05-19T14:40:14Z
dc.date.available2024-05-19T14:40:14Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAim: This study aimed to evaluate the expression levels of miR-99b and miR-135b in peritoneal carcinoma and liver metastases associated with Colorectal Cancer (CRC), assess their association with the intracellular signaling pathway proteins Kirsten Rat Sarcoma Virus (KRAS) and Akt, and investigate their effects on survival. Materials and methods: Changes in the KRAS gene and Akt proteins, expression levels of miR-99b and miR-135b, and factors affecting survival were compared between colorectal cancer-associated peritoneal carcinomatosis and liver metastasis. Results: The expression levels of miR-99b and miR-135b and the immunohistochemical grade classification score of Akt were higher in colorectal cancer, peritoneal carcinomatosis, and liver metastasis than in normal tissues < 0.05). MiR-99b expression was highest in CRC, whereas miR-135b expression was highest in peritoneal carcinomatosis (p < 0.05). The expression level of miR-99b decreased and that of miR-135b increased in peritoneal and liver metastases compared with that in the tumor tissue. MiR-99b, Akt, and recurrence were risk factors that affected the overall survival rate in the model of clinical predictions (p = 0.045, p = 0.006, and p = 0.012, respectively). Conclusion: While the expression of miR-99b was highest in the primary tumor, its decrease in liver metastasis and peritoneal carcinomatosis suggests that miR-99b has a protective effect against liver metastasis and peritoneal carcinomatosis. However, the detection of miR-135b expression was highest in peritoneal carcinomatosis and liver metastasis compared with that in the colorectal cancer tissues suggesting that it facilitates peritoneal carcinomatosis and liver metastasis. Furthermore, miR-99b, KRAS mutations, and Akt are risk factors for the overall survival of colorectal cancer.en_US
dc.identifier.doi10.1016/j.clinsp.2023.100271
dc.identifier.issn1807-5932
dc.identifier.issn1980-5322
dc.identifier.pmid37639911en_US
dc.identifier.scopus2-s2.0-85168720775en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org10.1016/j.clinsp.2023.100271
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4929
dc.identifier.volume78en_US
dc.identifier.wosWOS:001069263600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Espanaen_US
dc.relation.ispartofClinicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectColorectal Canceren_US
dc.subjectLiver Metastasisen_US
dc.subjectMir-99ben_US
dc.subjectMir-135ben_US
dc.subjectPeritonitis Carcinomatosisen_US
dc.titleEffect of the MiR-99b and MiR-135b on peritoneal carcinomatosis and liver metastasis in colorectal canceren_US
dc.typeArticleen_US

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