Long noncoding RNAs: A novel insight in the leukemogenesis and drug resistance in acute myeloid leukemia

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorKirtonia, Anuradha
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorZabolian, Amirhossein
dc.contributor.authorBejandi, Atefe K.
dc.contributor.authorRani, Reshma
dc.contributor.authorPandey, Amit K.
dc.contributor.authorBaligar, Prakash
dc.contributor.authorKumar, Vinit
dc.contributor.authorDas, Bhudev C.
dc.contributor.authorGarg, Manoj
dc.date.accessioned2022-01-28T08:37:11Z
dc.date.available2022-01-28T08:37:11Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractAcute myeloid leukemia (AML) is a common hematological disorder with heterogeneous nature that resulted from blocked myeloid differentiation and an enhanced number of immature myeloid progenitors. During several decades, different factors, including cytogenetic, genetic, and epigenetic have been reported to contribute to the pathogenesis of AML by inhibiting the differentiation and ensuring the proliferation of myeloid blast cells. Recently, long noncoding RNAs (lncRNAs) have been considered as potential diagnostic, therapeutic, and prognostic factors in different human malignancies including AML. Altered expression of lncRNAs is correlated with the transformation of hematopoietic stem and progenitor cells into leukemic blast cells because of their distinct role in the key cellular processes. We discuss the significant role of lncRNAs in the proliferation, survival, differentiation, leukemic stem cells in AML and their involvement in different molecular pathways (insulin-like growth factor type I receptor, FLT3, c-KIT, Wnt, phosphatidylinositol 3-kinase/protein kinase-B, microRNAs), and associated mechanisms such as autophagy, apoptosis, and glucose metabolism. In addition, we aim to highlight the role of lncRNAs as reliable biomarkers for diagnosis, prognosis, and drug resistance for precision medicine in AML.en_US
dc.identifier.citationKirtonia A, Ashrafizadeh M, Zarrabi A, Hushmandi K, Zabolian A, Bejandi AK, Rani R, Pandey AK, Baligar P, Kumar V, Das BC, Garg M. Long noncoding RNAs: A novel insight in the leukemogenesis and drug resistance in acute myeloid leukemia. J Cell Physiol. 2021 Sep 27.en_US
dc.identifier.doi10.1002/jcp.30590en_US
dc.identifier.pmid34569616en_US
dc.identifier.scopus2-s2.0-85115666147en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1002/jcp.30590
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2436
dc.identifier.wosWOS:000700082000001en_US
dc.identifier.wosqualityQ1 - Q2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofJournal of Cellular Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Myeloid Leukemiaen_US
dc.subjectChemoresistanceen_US
dc.subjectDifferentiationen_US
dc.subjectLong Noncoding RNAen_US
dc.subjectProliferationen_US
dc.titleLong noncoding RNAs: A novel insight in the leukemogenesis and drug resistance in acute myeloid leukemiaen_US
dc.typeReview Articleen_US

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