Cytotoxic and genotoxic effects of an endemic plant of Turkey salvia kronenburgii on breast cancer cell lines

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorÇebi, Ayşegül
dc.contributor.authorAkgün, Egemen
dc.contributor.authorÇelikler, Serap
dc.contributor.authorFırat, Mehmet
dc.contributor.authorÖzel, Mustafa Zafer
dc.contributor.authorUlukaya, Engin
dc.contributor.authorArı, Ferda
dc.date.accessioned2020-08-30T20:06:41Z
dc.date.available2020-08-30T20:06:41Z
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractContext: The natural products derived from plants are the important sources that can be used for breast cancer treatment. Salvia species and their derived products were recommended as potential antitumor substances. Aim: The potential cytotoxic and genotoxic effects of Salvia kronenburgii have been investigated on breast cancer cell lines, MCF-7 and MDA-MB-231. Materials and Methods: Determination of chemical compounds of S. kronenburgii was done using a gas chromatography coupled to time-of-flight mass spectrometry system and a dual-stage commercial thermal desorption injector. Growth inhibition of the S. kronenburgii was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ATP viability assays. The cell death mode was detected by fluorescent dyes. Genotoxic effect of S. kronenburgii was measured by comet assay. Results: S. kronenburgii showed antiproliferative effect in a dose-dependent manner on MCF-7 and MDA-MB-231 cell lines by inducing apoptosis-like cell death. The pyknotic cell nuclei were observed at the cell lines in response to S. kronenburgii. Furthermore, significant increase was shown in genetic damage index and frequencies in the damaged cells. Conclusion: S. kronenburgii might be a promising natural source for cancer therapy. Further experiments need to be done in vivo to understand of the anticancer effects of this plant.en_US
dc.description.sponsorshipUludag UniversityUludag University [BUAP (F)-2014/3]en_US
dc.description.sponsorshipWe thank the Research Fund of Uludag University for the project numbered BUAP (F)-2014/3 for providing us with the kits/chemicals. We would like to thank Buse Cevatemre for technical assistance.en_US
dc.identifier.citationÇebi, A., Akgün, E., Çelikler, S., Firat, M., Özel, M., Ulukaya, E., ... & Özel, M. Z. (2019). Cytotoxic and genotoxic effects of an endemic plant of Turkey on breast cancer cell lines. Journal of Cancer Research & Therapeutics, 15(5).en_US
dc.identifier.doi10.4103/jcrt.JCRT_1322_16en_US
dc.identifier.endpage1086en_US
dc.identifier.issn0973-1482en_US
dc.identifier.issn1998-4138en_US
dc.identifier.issue5en_US
dc.identifier.pmid31603114en_US
dc.identifier.scopus2-s2.0-85073095325en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1080en_US
dc.identifier.urihttps://doi.org/10.4103/jcrt.JCRT_1322_16
dc.identifier.urihttps://hdl.handle.net/20.500.12713/595
dc.identifier.volume15en_US
dc.identifier.wosWOS:000503180500021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal of Cancer Research and Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast Canceren_US
dc.subjectCytotoxicityen_US
dc.subjectGenotoxicityen_US
dc.subjectIn Vitroen_US
dc.subjectSalvia Kronenburgiien_US
dc.titleCytotoxic and genotoxic effects of an endemic plant of Turkey salvia kronenburgii on breast cancer cell linesen_US
dc.typeArticleen_US

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