Developing novel hydroxypropyl-?-cyclodextrin-based nanosponges as carriers for anticancer hydrophobic agents: Overcoming limitations of host-guest complexes in a comparative evaluation

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorPeimanfard, Shohreh
dc.contributor.authorZarrabi, Ali
dc.contributor.authorTrotta, Francesco
dc.contributor.authorMatencio, Adrián
dc.contributor.authorCecone, Claudio
dc.contributor.authorCaldera, Fabrizio
dc.date.accessioned2022-06-02T10:29:22Z
dc.date.available2022-06-02T10:29:22Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractThis study aimed to design and fabricate novel hydroxypropyl-?-cyclodextrin-based hypercrosslinked polymers, called nanosponges, as carriers for anticancer hydrophobic agents and compare them with host–guest complexes of hydroxypropyl-?-cyclodextrin, a remarkable solubilizer, to investigate their application in improving the pharmaceutical properties of the flavonoid naringenin, a model hydrophobic nutraceutical with versatile anticancer effects. For this purpose, three new nanosponges, crosslinked with pyromellitic dianhydride, citric acid, and carbonyldiimidazole, were fabricated. The carbonate nanosponge synthesized by carbonyldiimidazole presented the highest naringenin loading capacity (?19.42%) and exerted significantly higher antiproliferative effects against MCF-7 cancer cells compared to free naringenin. Additionally, this carbonate nanosponge formed a stable nanosuspension, providing several advantages over the naringenin/hydroxypropyl?-cyclodextrin host–guest complex, including an increase of about 3.62-fold in the loading capacity percentage, sustained released pattern (versus the burst pattern of host–guest complex), and up to an 8.3-fold increase in antiproliferative effects against MCF-7 cancer cells. Both naringenin-loaded carriers were less toxic to L929 murine fibroblast normal cells than MCF-7 cancer cells. These findings suggest that hydroxypropyl-?-cyclodextrin-based carbonate nanosponges could be a good candidate as a drug delivery system with potential applications in cancer treatment.en_US
dc.identifier.citationPeimanfard S, Zarrabi A, Trotta F, Matencio A, Cecone C, Caldera F. Developing Novel Hydroxypropyl-β-Cyclodextrin-Based Nanosponges as Carriers for Anticancer Hydrophobic Agents: Overcoming Limitations of Host-Guest Complexes in a Comparative Evaluation. Pharmaceutics. 2022 May 15;14(5):1059. doi: 10.3390/pharmaceutics14051059. PMID: 35631645; PMCID: PMC9147629.en_US
dc.identifier.doi10.3390/pharmaceutics14051059en_US
dc.identifier.issn1999-4923en_US
dc.identifier.issue5en_US
dc.identifier.pmid9147629en_US
dc.identifier.scopus2-s2.0-85130732775en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.3390/pharmaceutics14051059
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2779
dc.identifier.volume14en_US
dc.identifier.wosWOS:000803169700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherPMCen_US
dc.relation.ispartofPharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject2-hydroxypropyl-β-Cyclodextrinen_US
dc.subjectNanospongeen_US
dc.subjectHost–Guest Complexen_US
dc.subjectNaringeninen_US
dc.subjectDrug Delivery Systemsen_US
dc.subjectCytotoxicityen_US
dc.titleDeveloping novel hydroxypropyl-?-cyclodextrin-based nanosponges as carriers for anticancer hydrophobic agents: Overcoming limitations of host-guest complexes in a comparative evaluationen_US
dc.typeArticleen_US

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