The anti-amoebic potential of carboxamide derivatives containing sulfonyl or sulfamoyl moieties against brain-eating Naegleria fowleri

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dc.authoridKhan, Naveed/0000-0001-7667-8553
dc.authoridSiddiqui, Ruqaiyyah/0000-0001-9646-6208
dc.authoridZareei, Seyed Omar/0000-0002-0212-2146
dc.authoridAkbar, Noor/0000-0002-8114-1969
dc.authorwosidKhan, Naveed/KCK-0156-2024
dc.authorwosidKhan, Naveed/AAM-2892-2021
dc.authorwosidSiddiqui, Ruqaiyyah/AIF-2100-2022
dc.contributor.authorAkbar, Noor
dc.contributor.authorSiddiqui, Ruqaiyyah
dc.contributor.authorEl-Gamal, Mohammed I.
dc.contributor.authorZaraei, Seyed-Omar
dc.contributor.authorAlawfi, Bader S.
dc.contributor.authorKhan, Naveed Ahmed
dc.date.accessioned2024-05-19T14:45:55Z
dc.date.available2024-05-19T14:45:55Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractNaegleria fowleri is a free-living thermophilic flagellate amoeba that causes a rare but life-threatening infection called primary amoebic meningoencephalitis (PAM), with a very high fatality rate. Herein, the anti-amoebic potential of carboxamide derivatives possessing sulfonyl or sulfamoyl moiety was assessed against pathogenic N. fowleri using amoebicidal, cytotoxicity and cytopathogenicity assays. The results from amoebicidal experiments showed that derivatives dramatically reduced N. fowleri viability. Selected derivatives demonstrated IC50 values at lower concentrations; 1j showed IC50 at 24.65 mu M, while 1k inhibited 50% amoebae growth at 23.31 mu M. Compounds with significant amoebicidal effects demonstrated limited cytotoxicity against human cerebral microvascular endothelial cells. Finally, some derivatives mitigated N. fowleri-instigated host cell death. Ultimately, this study demonstrated that 1j and 1k exhibited potent anti-amoebic activity and ought to be looked at in future studies for the development of therapeutic anti-amoebic pharmaceuticals. Further investigation is required to determine the clinical relevance of our findings.en_US
dc.description.sponsorshipUniversity of Sharjah, Sharjah, United Arab Emirates [2101110153]en_US
dc.description.sponsorshipThe authors are grateful to University of Sharjah, Sharjah, United Arab Emirates, for financially supporting this study (grant No. 2101110153).en_US
dc.identifier.doi10.1007/s00436-023-07953-w
dc.identifier.endpage2548en_US
dc.identifier.issn0932-0113
dc.identifier.issn1432-1955
dc.identifier.issue11en_US
dc.identifier.pmid37665414en_US
dc.identifier.scopus2-s2.0-85169667312en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2539en_US
dc.identifier.urihttps://doi.org10.1007/s00436-023-07953-w
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5393
dc.identifier.volume122en_US
dc.identifier.wosWOS:001061899100001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofParasitology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectNaegleria Fowlerien_US
dc.subjectAmoebicidalen_US
dc.subjectCarboxamideen_US
dc.subjectSulfonylen_US
dc.subjectSulfamoylen_US
dc.subjectPrimary Amoebic Meningoencephalitisen_US
dc.subjectCytopathogenicityen_US
dc.titleThe anti-amoebic potential of carboxamide derivatives containing sulfonyl or sulfamoyl moieties against brain-eating Naegleria fowlerien_US
dc.typeArticleen_US

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