Prenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbations

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dc.authoridErdogan, Mumin Alper/0000-0003-0048-444X
dc.authorwosidErdogan, Mumin Alper/AAR-3140-2021
dc.contributor.authorErdogan, Mumin Alper
dc.contributor.authorGurbuz, Orkun
dc.contributor.authorBozkurt, Mehmet Fatih
dc.contributor.authorErbas, Oytun
dc.date.accessioned2024-05-19T14:40:33Z
dc.date.available2024-05-19T14:40:33Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThe COVID-19 pandemic catalyzed the swift development and distribution of mRNA vaccines, including BNT162b2, to address the disease. Concerns have arisen about the potential neurodevelopmental implications of these vaccines, especially in susceptible groups such as pregnant women and their offspring. This study aimed to investigate the gene expression of WNT, brain-derived neurotrophic factor (BDNF) levels, specific cytokines, m-TOR expression, neuropathology, and autism-related neurobehavioral outcomes in a rat model. Pregnant rats received the COVID-19 mRNA BNT162b2 vaccine during gestation. Subsequent evaluations on male and female offspring included autism-like behaviors, neuronal counts, and motor performance. Molecular techniques were applied to quantify WNT and m-TOR gene expressions, BDNF levels, and specific cytokines in brain tissue samples. The findings were then contextualized within the extant literature to identify potential mechanisms. Our findings reveal that the mRNA BNT162b2 vaccine significantly alters WNT gene expression and BDNF levels in both male and female rats, suggesting a profound impact on key neurodevelopmental pathways. Notably, male rats exhibited pronounced autism-like behaviors, characterized by a marked reduction in social interaction and repetitive patterns of behavior. Furthermore, there was a substantial decrease in neuronal counts in critical brain regions, indicating potential neurodegeneration or altered neurodevelopment. Male rats also demonstrated impaired motor performance, evidenced by reduced coordination and agility. Our research provides insights into the effects of the COVID-19 mRNA BNT162b2 vaccine on WNT gene expression, BDNF levels, and certain neurodevelopmental markers in a rat model. More extensive studies are needed to confirm these observations in humans and to explore the exact mechanisms. A comprehensive understanding of the risks and rewards of COVID-19 vaccination, especially during pregnancy, remains essential.en_US
dc.description.sponsorshipIzmir Katip Celebi Universityen_US
dc.description.sponsorshipNo Statement Availableen_US
dc.identifier.doi10.1007/s11064-023-04089-2
dc.identifier.endpage1048en_US
dc.identifier.issn0364-3190
dc.identifier.issn1573-6903
dc.identifier.issue4en_US
dc.identifier.pmid38198049en_US
dc.identifier.scopus2-s2.0-85181906873en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1034en_US
dc.identifier.urihttps://doi.org10.1007/s11064-023-04089-2
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4979
dc.identifier.volume49en_US
dc.identifier.wosWOS:001138782800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer/Plenum Publishersen_US
dc.relation.ispartofNeurochemical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCovid-19en_US
dc.subjectMrna Vaccineen_US
dc.subjectBnt162b2en_US
dc.subjectNeurodevelopmental Disordersen_US
dc.subjectWnt Pathwayen_US
dc.subjectBrain-Derived Neurotrophic Factor (Bdnf)en_US
dc.titlePrenatal Exposure to COVID-19 mRNA Vaccine BNT162b2 Induces Autism-Like Behaviors in Male Neonatal Rats: Insights into WNT and BDNF Signaling Perturbationsen_US
dc.typeArticleen_US

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