A novel ganciclovir resistance mutation in the UL97 gene of the HHV-5 in an adult hematopoietic stem cell transplant recipient
Yükleniyor...
Dosyalar
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Future Medicine Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Therapeutic management of cytomegalovirus (CMV) disease in hematopoietic stem cell transplantation patients can become a challenge because of the emergence of anti-CMV drug resistance. This case report presents a patient with clinical ganciclovir resistance due to a new mutation: histidine-to-asparagine change at residue 393 of UL97. This mutation, which is located in the nonfunctional region of the UL97 gene, is very unusual. Having more information about the mutations leading to drug resistance in CMV is important for both improved clinical management and development of new diagnostic tests and drugs.
Açıklama
Anahtar Kelimeler
Cytomegalovirus, Ganciclovir Resistance, Ul97 Mutation
Kaynak
Future Virology
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
12
Sayı
12
Künye
Hancer, V. S., Yarimcan, F. S., Buyukdogan, M., Aki, S. Z., Oksuz, B., Acar, K., … Bulut, P. (2017). A novel ganciclovir resistance mutation in the UL97 gene of the HHV-5 in an adult hematopoietic stem cell transplant recipient. Future Virology, 12(12), 761–766. https://doi.org/10.2217/fvl-2017-0085
