A novel ganciclovir resistance mutation in the UL97 gene of the HHV-5 in an adult hematopoietic stem cell transplant recipient

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dc.authoridVeysel Sabri Hançer / 0000-0003-2994-1077en_US
dc.authoridMuradiye Acar / 0000-0003-4357-5229en_US
dc.authoridFiliz Sağlam Yarımcan / 0000-0001-8267-0435
dc.authoridMurat Büyükdoğan / 0000-0001-7948-0235
dc.authoridPelin Bulut / 0000-0002-2070-7375
dc.authorscopusidFiliz Sağlam Yarımcan / 57199153940
dc.authorscopusidMurat Büyükdoğan / 35247676100
dc.authorscopusidBurcu Öksüz / 57203002136
dc.authorscopusidPelin Bulut / 56495230800
dc.authorscopusidVeysel Sabri Hançer / 6506533543
dc.authorscopusidMuradiye Acar / 50261019400
dc.authorwosidFiliz Sağlam Yarımcan / IWD-5094-2023
dc.authorwosidMurat Büyükdoğan / Y-2855-2018
dc.authorwosidBurcu Öksüz / JRA-2732-2023
dc.authorwosidPelin Bulut / CJE-6223-2022
dc.authorwosidVeysel Sabri Hançer / X-8971-2018
dc.authorwosidMuradiye Acar / B-6537-2019
dc.contributor.authorHançer, Veysel Sabri
dc.contributor.authorSağlam Yarımcan, Filiz
dc.contributor.authorBüyükdoğan, Murat
dc.contributor.authorAkı, Şahika Zeynep
dc.contributor.authorÖksüz, Burcu
dc.contributor.authorAcar, Kadir
dc.contributor.authorAcar, Muradiye
dc.contributor.authorBulut, Pelin
dc.date.accessioned2020-08-30T20:07:59Z
dc.date.available2020-08-30T20:07:59Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractTherapeutic management of cytomegalovirus (CMV) disease in hematopoietic stem cell transplantation patients can become a challenge because of the emergence of anti-CMV drug resistance. This case report presents a patient with clinical ganciclovir resistance due to a new mutation: histidine-to-asparagine change at residue 393 of UL97. This mutation, which is located in the nonfunctional region of the UL97 gene, is very unusual. Having more information about the mutations leading to drug resistance in CMV is important for both improved clinical management and development of new diagnostic tests and drugs.en_US
dc.identifier.citationHancer, V. S., Yarimcan, F. S., Buyukdogan, M., Aki, S. Z., Oksuz, B., Acar, K., … Bulut, P. (2017). A novel ganciclovir resistance mutation in the UL97 gene of the HHV-5 in an adult hematopoietic stem cell transplant recipient. Future Virology, 12(12), 761–766. https://doi.org/10.2217/fvl-2017-0085en_US
dc.identifier.doi10.2217/fvl-2017-0085en_US
dc.identifier.endpage765en_US
dc.identifier.issn1746-0794en_US
dc.identifier.issn1746-0808en_US
dc.identifier.issue12en_US
dc.identifier.scopus2-s2.0-85037647334en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage760en_US
dc.identifier.urihttps://doi.org/10.2217/fvl-2017-0085
dc.identifier.urihttps://hdl.handle.net/20.500.12713/864
dc.identifier.volume12en_US
dc.identifier.wosWOS:000416975700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorHançer, Veysel Sabrien_US
dc.institutionauthorSağlam Yarımcan, Filizen_US
dc.institutionauthorBüyükdoğan, Muraten_US
dc.institutionauthorÖksüz, Burcuen_US
dc.institutionauthorAcar, Muradiyeen_US
dc.institutionauthorBulut, Pelinen_US
dc.language.isoenen_US
dc.publisherFuture Medicine Ltden_US
dc.relation.ispartofFuture Virologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCytomegalovirusen_US
dc.subjectGanciclovir Resistanceen_US
dc.subjectUl97 Mutationen_US
dc.titleA novel ganciclovir resistance mutation in the UL97 gene of the HHV-5 in an adult hematopoietic stem cell transplant recipienten_US
dc.typeArticleen_US

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