Ionizing radiation exposure due to medical imaging in hematopoietic stem cell transplant recipients

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dc.authoridIşıl Yurdaışık / 0000-0001-8316-1229en_US
dc.authorscopusidIşıl Yurdaışık / 57211471093
dc.authorwosidIşıl Yurdaışık / AAL-9433-2020en_US
dc.contributor.authorAksoy, Süleyman Hilmi
dc.contributor.authorYurdaışık, Işıl
dc.contributor.authorTimurağaoğlu, Ayşen
dc.date.accessioned2022-06-15T14:22:46Z
dc.date.available2022-06-15T14:22:46Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractIntroduction: The study aimed to quantify the ionizing radiation exposure of patients with hematologic malignancy who underwent hematopoietic stem cell transplantation (HSCT). Methods: This was a retrospective evaluation of the adult patients who underwent allogeneic or autologous HSCT for hematologic malignities in a single center between January 2016 and September 2020. All radiological imaging procedures involving ionizing radiation screened study participants. The study period covered both the pre- and post-transplantation phases. A typical cumulative effective dose (CED) was used to calculate the exposed ionizing radiation in units of millisieverts (mSv). Results: A total of 120 patients (females 38.3%, mean age: 52.2 +/- 15.6 years) were included. Autologous HSCT was performed in 66 patients (55%), whereas 54 patients (45%) underwent allogeneic HSCT. Patients with acute myeloid leukemia and acute lymphoblastic leukemia comprised 53.7% and 31.5% of allogeneic HSCT, respectively. Autologous HSCT was mainly performed in patients with multiple myeloma (47%) and non-hodgkin lymphoma (34.8%). The median total CED was 11.85 mSv (interquartile range: 4.08-19.78). The median CED of allogeneic HSCT patients was significantly higher than that of the autologous HSCT group. The vast majority of the total CED (92.3%) comes from computed tomography imaging procedures. In the entire groups, 92 patients (76.7%) received a low dose (<20 mSv), whereas 26 patients (21.7%) received a moderate dose (>20-50 mSv) ionizing radiation. Conclusion: One-third of all HSCT patients received a moderate ionizing radiation dose. Allogeneic HSCT patients had significantly higher median CED than autologous counterparts.en_US
dc.identifier.doi10.4274/imj.galenos.2022.40771en_US
dc.identifier.endpage124en_US
dc.identifier.issn2619-9793en_US
dc.identifier.issue2en_US
dc.identifier.startpage119en_US
dc.identifier.trdizinid520567en_US
dc.identifier.urihttps://doi.org/10.4274/imj.galenos.2022.40771
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2905
dc.identifier.volume23en_US
dc.identifier.wosWOS:000803867300008en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorYurdaışık, Işıl
dc.language.isoenen_US
dc.publisherISTANBUL TRAINING & RESEARCH HOSPITALen_US
dc.relation.ispartofISTANBUL MEDICAL JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectComputed Tomographyen_US
dc.subjectCumulative Effective Doseen_US
dc.subjectIonizing Radiationen_US
dc.subjectRadiation Exposureen_US
dc.subjectHematopoietic Stem Cell Transplantationen_US
dc.titleIonizing radiation exposure due to medical imaging in hematopoietic stem cell transplant recipientsen_US
dc.typeArticleen_US

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