The effects of the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin, cannabinoid agonist WIN 55,212-2, and nitric oxide synthase inhibitor n?-nitro-l-arginine methyl ester hydrochloride on the serotonin and dry skin-induced itch

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dc.authoridFatma Kübra Tombultürk / 0000-0002-4358-2309en_US
dc.authorscopusidFatma Kübra Tombultürk / 56748052500
dc.authorwosidFatma Kübra Tombultürk / L-3969-2018
dc.contributor.authorTodurga Seven, Zeynep Gizem
dc.contributor.authorTombultürk, Fatma Kübra
dc.contributor.authorGökdemir, Selim
dc.contributor.authorÖzyazgan, Sibel
dc.date.accessioned2021-12-08T11:03:29Z
dc.date.available2021-12-08T11:03:29Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Bölümüen_US
dc.description.abstractIntroduction: In many types of itch, the interaction between immune system cells, keratinocytes, and sensory nerves involved in the transmission of itch is quite complex. Especially for patients with chronic itching, current treatments are insufficient, and their quality of life deteriorates significantly. Objective: In this study, we aimed to investigate the role of the heat shock protein 90 (Hsp90) inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG), cannabinoid agonist WIN 55,212-2, and nitric oxide (NO) synthase inhibitor N?-nitro-L-arginine methyl ester hydrochloride (L-NAME) in pruritus. Methods: We created a serotonin (5-HT)-induced (50 ?g/?L/mouse, i.d.) acute and acetone-ether-water (AEW)-induced chronic itching models. 17-AAG (1, 3, and 5 mg/kg, intraperitoneally [i.p.]), WIN 55,212-2 (1 mg/kg, i.p.), and L-NAME (1 mg/kg, i.p.) were applied to Balb/c mice. Results: We found that 17-AAG suppressed the scratches of mice, depending on the dose. The itch behavior was reduced by WIN 55,212-2, but L-NAME showed no antipruritic effect at the administered dose. The combined application of these agents in both pruritus models showed synergism in terms of the antipruritic effect. Our results showed that NO did not play a role in the antipruritic effect of WIN 55,212-2 and 17-AAG. Increased plasma IgE levels with AEW treatment decreased with the administration of 17-AAG (5 mg/kg, i.p.) and WIN 55,212-2. Conclusion: These results demonstrate that Hsp90 may play a role in the peripheral pathway of pruritus, and cannabinoid agonists and Hsp90 inhibitors can be used together in the treatment of pruritus.en_US
dc.identifier.citationTodurga Seven, Z. G., Tombulturk, F. K., Gokdemir, S., & Ozyazgan, S. (2021). The Effects of the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin, Cannabinoid Agonist WIN 55,212-2, and Nitric Oxide Synthase Inhibitor Nω-Nitro-L-Arginine Methyl Ester Hydrochloride on the Serotonin and Dry Skin-Induced Itch. International archives of allergy and immunology, 1–10. Advance online publication.en_US
dc.identifier.doi10.1159/000520509en_US
dc.identifier.pmid34864727en_US
dc.identifier.scopus2-s2.0-85121309783en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1159/000520509
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2315
dc.identifier.wosWOS:000728891900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTombultürk, Fatma Kübra
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofInternational Archives of Allergy and Immunologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCannabinoiden_US
dc.subjectHeat Shock Protein 90en_US
dc.subjectIgEen_US
dc.subjectNitric Oxideen_US
dc.subjectPruritusen_US
dc.subjectSerotoninen_US
dc.titleThe effects of the heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin, cannabinoid agonist WIN 55,212-2, and nitric oxide synthase inhibitor n?-nitro-l-arginine methyl ester hydrochloride on the serotonin and dry skin-induced itchen_US
dc.typeArticleen_US

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