A Retrospective Analysis of 83 Patients with Testicular Mass Who Underwent Testis-Sparing Surgery: The Eurasian Uro-oncology Association Multicenter Study

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dc.authoridKaygısız, Onur/0000-0002-9790-7295
dc.authoridÇOLAKOĞLU, Yunus/0000-0001-6432-765X
dc.authoridhamidi, nurullah/0000-0002-6825-1813
dc.authoridTUNCEL, ALTUG/0000-0003-2482-797X
dc.authoridKESKE, MURAT/0000-0001-6591-4506
dc.authoridSoytas, Mustafa/0000-0002-3474-3510
dc.authorwosidKaygısız, Onur/L-9439-2019
dc.authorwosidÇOLAKOĞLU, Yunus/HGB-0095-2022
dc.authorwosidhamidi, nurullah/HHM-9194-2022
dc.authorwosidTUNCEL, ALTUG/ABY-1590-2022
dc.authorwosidKESKE, MURAT/T-3436-2018
dc.contributor.authorKeske, Murat
dc.contributor.authorCanda, Abdullah Erdem
dc.contributor.authorKaradag, Mert Ali
dc.contributor.authorCiftci, Halil
dc.contributor.authorErturhan, Sakip
dc.contributor.authorKactan, Cagri
dc.contributor.authorSoytas, Mustafa
dc.date.accessioned2024-05-19T14:46:10Z
dc.date.available2024-05-19T14:46:10Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractIntroduction: Herein, we analyzed the histopathological, oncological and functional outcomes of testis-sparing surgery (TSS) in patients with distinct risk for testicular cancer. Methods: This is a multicenter retrospective study on consecutive patients who underwent TSS. Patients were categorized in high- or low-risk testicular germ cell tumor (TGCT) according to the presence/absence of features compatible with testicular dysgenesis syndrome. Histology was categorized per size and risk groups. Results: TSS was performed in 83 patients (86 tumors) of them, 27 in the high-risk group. Fifty-nine patients had a non-tumoral contralateral testis present. Sixty masses and 26 masses were benign and TGCTs, respectively. No statistical differences were observed in mean age (30.9 +/- 10.32 years), pathological tumor size (14.67 +/- 6.7 mm) between risk groups or between benign and malignant tumors (p = 0.608). When categorized per risk groups, 22 (73.3%) and 4 (7.1%) of the TSS specimens were malignant in the high- and low-risk patient groups, respectively. Univariate analysis showed that the only independent variable significantly related to malignant outcome was previous history of TGCT. During a mean follow-up of 25.5 +/- 22.7 months, no patient developed systemic disease. Local recurrence was detected in 5 patients and received radical orchiectomy. Postoperative testosterone levels remained normal in 88% of those patients with normal preoperative level. No erectile dysfunction was reported in patients with benign lesions. Conclusion: TSS is a safe and feasible approach with adequate cancer control, and preservation of sexual function is possible in 2/3 of patients harboring malignancy. Incidence of TGCT varies extremely between patients at high and low risk for TGCT requiring a careful consideration and counseling.en_US
dc.identifier.doi10.1159/000531645
dc.identifier.endpage865en_US
dc.identifier.issn0042-1138
dc.identifier.issn1423-0399
dc.identifier.issue9en_US
dc.identifier.pmid37591208en_US
dc.identifier.scopus2-s2.0-85170556538en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage857en_US
dc.identifier.urihttps://doi.org10.1159/000531645
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5457
dc.identifier.volume107en_US
dc.identifier.wosWOS:001102611400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofUrologia Internationalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPartial Orchiectomyen_US
dc.subjectTestis-Sparing Surgeryen_US
dc.subjectTesticular Tumoren_US
dc.subjectGerm Cell Testicular Canceren_US
dc.titleA Retrospective Analysis of 83 Patients with Testicular Mass Who Underwent Testis-Sparing Surgery: The Eurasian Uro-oncology Association Multicenter Studyen_US
dc.typeArticleen_US

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