Evaluation of the risk factors for BK virus-associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does post-transplantation cyclophosphamide increase the frequency?

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dc.authoridMurat Sütçü / 0000-0002-2078-9796en_US
dc.authoridOzan Özkaya / 0000-0002-0198-1221
dc.authorscopusidMurat Sütçü / 55499199300
dc.authorscopusidOzan Özkaya / 7003365098
dc.authorwosidMurat Sütçü / AAR-5212-2020en_US
dc.authorwosidOzan Özkaya / AAO-2136-2020en_US
dc.contributor.authorZengin Ersoy, Gizem
dc.contributor.authorBozkurt, Ceyhun
dc.contributor.authorAdaklı Aksoy, Başak
dc.contributor.authorBaşoğlu Öner, Özlem
dc.contributor.authorAydoğdu, Selime
dc.contributor.authorÇipe, Funda
dc.contributor.authorSütçü, Murat
dc.contributor.authorÖzkaya, Ozan
dc.contributor.authorTunç, Fışgın
dc.date.accessioned2022-07-21T06:08:10Z
dc.date.available2022-07-21T06:08:10Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: BKV-HC is one of the most significant complications of HSCT. This ret -rospective study aimed to determine the frequency of BKV-HC in pediatric patients undergoing HSCT, detect the associated risk factors for the development of BKV-HC, and explore the effects of post-transplantation Cy use.Methods: Three hundred twenty-seven patients (girls: 121, boys: 206) were analyzed according to sex, conditioning regimen, transplantation type, donor relatedness, stem cell source, the presence and grade of aGVHD, CMV co-existence, and Cy use.Results: Multivariate analysis confirmed the prognostic importance of age (OR: 4.865), TBI use, the presence of aGVHD (OR: 2.794), CMV coinfection (OR: 2.261), and Cy use (OR: 27.353). A statistically significant difference was found between the mean BKV-HC follow-up times compared with post-transplantation Cy intake (p< .001). The BKV-HC rate increased as the number of risk factors of the patient increased.Conclusion: BKV-HC is an essential complication of HSCT primarily associated with Cy use, the presence of aGVHD, and donor relatedness. The present study shows that the use of Cy in the post-transplantation period further increases BKV-HC risk in pediatric patients, regardless of dose.en_US
dc.identifier.citationErsoy GZ, Bozkurt C, Aksoy BA, Öner ÖB, Aydoğdu S, Çipe F, Sütçü M, Özkaya O, Fışgın T. Evaluation of the risk factors for BK virus-associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does post-transplantation cyclophosphamide increase the frequency? Pediatr Transplant. 2022 Jul 19:e14364. doi: 10.1111/petr.14364. Epub ahead of print. PMID: 35851981.en_US
dc.identifier.doi10.1111/petr.14364en_US
dc.identifier.pmid35851981en_US
dc.identifier.scopus2-s2.0-85134192838en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttp://doi.org/10.1111/petr.14364
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3032
dc.identifier.wosWOS:000826868600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzkaya, Ozan
dc.institutionauthorSütçü, Murat
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofPediatric Transplantationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBK Virus Hemorrhagic Cystitisen_US
dc.subjectPost Transplantation Cyclophosphamideen_US
dc.subjectStem Cell Transplantationen_US
dc.titleEvaluation of the risk factors for BK virus-associated hemorrhagic cystitis in pediatric bone marrow transplantation patients: Does post-transplantation cyclophosphamide increase the frequency?en_US
dc.typeArticleen_US

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