Some bryophytes trigger cytotoxicity of stem cell-like population in 5-fluorouracil resistant colon cancer cells

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dc.authoridDilşad Özerkan / 0000-0002-0556-3879en_US
dc.authorscopusidDilşad Özerkan / 56805133700
dc.authorwosidDilşad Özerkan / AAC-3485-2021
dc.contributor.authorÖzerkan, Dilşad
dc.contributor.authorErol, Ayşe
dc.contributor.authorAltuner, Ergin Murat
dc.contributor.authorCanlı, Kerem
dc.contributor.authorKuruca, Dürdane Serap
dc.date.accessioned2021-06-25T08:19:03Z
dc.date.available2021-06-25T08:19:03Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümüen_US
dc.description.abstractColorectal cancer is the third most common cancer worldwide. Cancer stem cells are known to play an important role in relapse, and metastases of the disease after chemotherapy. Investigation of new drugs, and their combinations targeting these cells and thus eliminating cancer is one of the most urgent needs of today’s chemotherapy. The aim of the present study was to evaluate the effects of Bryophytes like Abietinella abietina (AA), Homolothecium sericeum (HS), Tortella tortuosa (TT), Syntrichia ruralis (SR), and Bryoerythrophyllum rubrum (BR) species extracted with ethyl alcohol on 5-fluorouracil(5-FU) resistant colorectal cancer cell lines (HCT116 and HT29). After extraction, stock solutions of bryophytes were prepared, and IC50 values were detected in drug-resistant cells obtained with 5-FU application. CD24+, CD44+/CD133+ surface markers and P?glycoprotein (P-gp) mediated efflux were isolated from both 5-FU treated cells and analyzed using the flow cytometry. In all bryophyte-treated groups, the binding Rho123low (low Rho fluorescence) and Rhohigh (high Rho fluorescence) were sorted from 5-FU resistant HCT116, and HT-29 cells. All types of bryophytes were found cytotoxic. Bryophyte extract reduced the percentage of Rholow cells in cultures incubated with 5-FU. In summary, the implementation of these bryophytes might be regarded as an effective approach for treatment of colorectal cancer due to their cytotoxic effect that decreases the recurrence of the disease.en_US
dc.identifier.citationDilşad Özerkan, Ayşe Erol, Ergin Murat Altuner, Kerem Canlı & Dürdane SerapKuruca (2021): Some Bryophytes Trigger Cytotoxicity of Stem Cell-like Population in 5-FluorouracilResistant Colon Cancer Cells, Nutrition and Cancer, DOI: 10.1080/01635581.2021.1933098en_US
dc.identifier.doi10.1080/01635581.2021.1933098en_US
dc.identifier.endpage11en_US
dc.identifier.pmid34151658en_US
dc.identifier.scopus2-s2.0-85108249838en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1080/01635581.2021.1933098
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1841
dc.identifier.wosWOS:000664604500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzerkan, Dilşad
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofNutrition and Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleSome bryophytes trigger cytotoxicity of stem cell-like population in 5-fluorouracil resistant colon cancer cellsen_US
dc.typeArticleen_US

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