Overt hypogonadism is a cardiovascular risk factor in type 2 diabetic males: an observational study

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dc.authoridAyten Oğuz / 0000-0002-9518-8610en_US
dc.authorscopusidAyten Oğuz / 35747046200
dc.authorwosidAyten Oğuz / AAV-5193-2021
dc.contributor.authorOğuz, Ayten
dc.contributor.authorŞahin, Murat
dc.contributor.authorÜlgen, Cansu
dc.contributor.authorUyan, Merve
dc.contributor.authorGül, Kamile
dc.date.accessioned2021-10-13T13:13:54Z
dc.date.available2021-10-13T13:13:54Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractWe aimed to evaluate the effects of hypogonadism on metabolic and chronic complications in type 2 diabetic males. 261 nonobese males with type 2 diabetes aged 18-70 were involved in the study. Hypononadal males were divided into 2 groups as overt hypogonadism (total testosterone?230 ng/dl) and borderline hypogonadism (230-345 ng/dl). The control group involved eugonadal diabetic males. Micro-macrovascular complications were recorded. 101 patients had hypogonadism (38.7%), and 160 patients were eugonadal (61.3%). Microvascular complication rate was not different, but macrovascular complication rate was significantly higher in hypogonadal males (42.6%/31.3%, p = 0.042). Optimal glycosylated haemoglobin (HbA1c) achievement(<7%) was significantly lower in hypogonadal patients (20.8%/31.3%, p = 0.043). Poor glycaemic control (HbA1c?7%), presence of microvascular complication and increased triglyceride levels were independent risk factors for hypogonadism (OR: 1.5, p = 0.044;OR:3.89,p = 0.025 and OR: 1.0, p = 0.016 respectively). Overt hypogonadism, hypertension, hypercholesterolaemia and severe hypoglycaemia were independent risk factors for macrovascular complications (OR: 1.0, p = 0.027; OR:2.6, p = 0.002; OR: 1.8, p = 0.047 and OR: 1.0, p = 0.007 respectively), diabetes duration (?5 years) and poor glycaemic control for microvascular complication (OR: 1.0, p = 0.031 and OR:2.0, p = 0.028). As a result, hypogonadism is frequent among diabetic males and poor glycaemic control may be an important contributing factor. Furthermore overt hypogonadism is an important cardiovascular risk marker. Therefore, ensuring eugonadism in diabetic patients may positively affect both glycaemic control and complications.en_US
dc.identifier.citationOguz, A., Sahin, M., Ulgen, C., Uyan, M., & Gul, K. (2021). Overt hypogonadism is a cardiovascular risk factor in type 2 diabetic males: An observational study. Andrologia, e14271. Advance online publication.en_US
dc.identifier.doi10.1111/and.14271en_US
dc.identifier.issn1439-0272en_US
dc.identifier.pmid34632609en_US
dc.identifier.scopus2-s2.0-85116798701en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1111/and.14271
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2147
dc.identifier.wosWOS:000705117300001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOğuz, Ayten
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofAndrologia.en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetic Chronic Complicationsen_US
dc.subjectGlycaemic Controlen_US
dc.subjectOvert Hypogonadismen_US
dc.titleOvert hypogonadism is a cardiovascular risk factor in type 2 diabetic males: an observational studyen_US
dc.typeArticleen_US

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