Associations of semen quality with pyrethroids in semen and urine samples of men with oligozoospermia: A cross-sectional study in Samsun, Turkey

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dc.authoridyazar, selma/0000-0003-2626-4066
dc.contributor.authorAlagoz, Murat
dc.contributor.authorYazar, Selma
dc.contributor.authorCanbay, Hale Secilmis
dc.contributor.authorAcikgoz, Abdullah
dc.contributor.authorCorba, Burcin S.
dc.date.accessioned2024-05-19T14:46:23Z
dc.date.available2024-05-19T14:46:23Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPyrethroids (PYRs) may act as endocrine disrupters and lead to infertility. The aim of the study was to analyze the levels of anti-androgenic PYRs (cypermethrin, deltamethrin, and permethrin) and 3-phenoxy benzoic acid (3-PBA), a general metabolite of PYRs, in both semen and urine samples of men with oligozoospermia. The PYRs and 3-PBA metabolite levels in the semen and urine samples of the men were analyzed through GC-MS. The results indicated that the levels of PYRs in the semen samples of the infertile group were significantly higher than those of the fertile group. It was determined that cypermethrin exposure was associated with changes in sperm count and total sperm motility, while permethrin, deltamethrin, and 3-PBA levels were associated with changes in sperm morphology. It was determined that there was a significant negative correlation between semen deltamethrin levels and sperm morphology and sperm count. In addition, exposure of these patients to deltamethrin (range; 1.53-8.02 mu g/l) and having farmer parents were determined to increase the risk of infertility. In conclusion, the findings of this study showed that exposure to environmental PYRs may adversely affect semen quality, especially in terms of sperm morphology, in men with oligozoospermia.en_US
dc.description.sponsorshipIstanbul Yeni Yuzyil University Scientific Research Projects Unit [IYYU BAP-AP-2021-5]en_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Istanbul Yeni Yuzyil University Scientific Research Projects Unit. Project Number: IYYU BAP-AP-2021-5.en_US
dc.identifier.doi10.1177/07482337231209356
dc.identifier.endpage761en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue12en_US
dc.identifier.pmid37860951en_US
dc.identifier.scopus2-s2.0-85174467724en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage754en_US
dc.identifier.urihttps://doi.org10.1177/07482337231209356
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5509
dc.identifier.volume39en_US
dc.identifier.wosWOS:001087631400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPyrethroidsen_US
dc.subjectAnti-Androgenicen_US
dc.subjectSemenen_US
dc.subjectOligospermiaen_US
dc.subjectMale Infertilityen_US
dc.titleAssociations of semen quality with pyrethroids in semen and urine samples of men with oligozoospermia: A cross-sectional study in Samsun, Turkeyen_US
dc.typeArticleen_US

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