Comparison of microfluid sperm sorting chip and density gradient methods for use in intrauterine insemination cycles

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dc.authoridAhmet Zeki Işık / 0000-0002-4717-2665
dc.authorscopusidAhmet Zeki Işık / 56400515200
dc.authorwosidAhmet Zeki Işık / AAO-4226-2020
dc.contributor.authorGode, Funda
dc.contributor.authorBodur, Taylan
dc.contributor.authorGüntürkün, Fatma
dc.contributor.authorGürbuz, Ali Sami
dc.contributor.authorTamer, Burcu
dc.contributor.authorPala, İbrahim
dc.contributor.authorIşık, Ahmet Zeki
dc.date.accessioned2020-08-30T20:06:28Z
dc.date.available2020-08-30T20:06:28Z
dc.date.issued2019
dc.departmentİstinye Üniversitesien_US
dc.description.abstractObjective: To compare the effect of microfluiding sperm sorting chip and density gradient methods on ongoing pregnancy rates (PRs) of patients undergoing IUI. Design: Retrospective cohort study. Setting: Hospital IVF unit. Patient(s): Couples with infertility undergoing IUI cycles between 2017 and 2018. Intervention(s): Not applicable. Main Outcome Measure(s): Ongoing PRs. Result(s): A total of 265 patients were included in the study. Microfluid sperm sorting and density gradient were used to prepare sperm in 133 and 132 patients, respectively. Baseline spermiogram parameters, including volume, concentration, motility, and morphology, were similar between the two groups. Total motile sperm count was lower in the microfluiding sperm sorting group at baseline (35.96 +/- 37.69 vs. 70.66 +/- 61.65). After sperm preparation sperm motility was higher in the microfluid group (96.34 +/- 7.29 vs. 84.42 +/- 10.87). Pregnancy rates were 18.04% in the microfluid group and 15.15% in the density gradient group, and ongoing PRs were 15.03% and 9.09%, respectively. After using multivariable logistic regression and controling for confounding factors, there was a significant increase in ongoing PRs in the microfluid sperm sorting group. The adjusted odds ratio for ongoing pregnancy in the microfluid group compared with the density gradient group was 3.49 (95% confidence interval 1.12-10.89). Conclusion(s): The microfluid sperm sorting method significantly increased the ongoing PRs compared with the density gradient group in IUI cycles. (C) 2019 by American Society for Reproductive Medicine.)en_US
dc.identifier.citationGode, F., Bodur, T., Gunturkun, F., Gurbuz, A. S., Tamer, B., Pala, I., & Isik, A. Z. (2019). Comparison of microfluid sperm sorting chip and density gradient methods for use in intrauterine insemination cycles. Fertility and Sterility, 112(5), 842-848.en_US
dc.identifier.doi10.1016/j.fertnstert.2019.06.037en_US
dc.identifier.endpage+en_US
dc.identifier.issn0015-0282en_US
dc.identifier.issn1556-5653en_US
dc.identifier.issue5en_US
dc.identifier.pmid31543253en_US
dc.identifier.scopus2-s2.0-85072284345en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage842en_US
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2019.06.037
dc.identifier.urihttps://hdl.handle.net/20.500.12713/528
dc.identifier.volume112en_US
dc.identifier.wosWOS:000496781300021en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorIşık, Ahmet Zekien_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility and Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMicrofluid Sperm Sortingen_US
dc.subjectPregnancy Ratesen_US
dc.subjectDensity Gradienten_US
dc.subjectIntrauterine Insemination Cyclesen_US
dc.subjectMicrochipen_US
dc.titleComparison of microfluid sperm sorting chip and density gradient methods for use in intrauterine insemination cyclesen_US
dc.typeArticleen_US

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