Comparison of the effects of dovitinib and bevacizumab on reducing neovascularization in an experimental rat corneal neovascularization model

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dc.authoridSiğnem Eyüboğlu / 0000-0002-0253-2217en_US
dc.authorscopusidSiğnem Eyüboğlu / 57210738678
dc.authorwosidSiğnem Eyüboğlu / AAR-5224-2020
dc.contributor.authorSahan, Berna
dc.contributor.authorÇiftçi, Ferda
dc.contributor.authorEyüboğlu , Siğnem
dc.contributor.authorUçar, Aylin Yaba
dc.contributor.authorYılmaz, Bayram
dc.contributor.authorYalvaç, Belkıs Ilgaz
dc.date.accessioned2020-08-30T20:06:35Zen_US
dc.date.available2020-08-30T20:06:35Zen_US
dc.date.issued2019
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: To compare the inhibitory effects of dovitinib and bevacizumab for treatment of corneal neovascularization (CNV). Methods: Thirty-nine adult female Sprague Dawley rats weighing 180 to 250 g were used. CNV was induced by silver nitrate in the right eye of each rat. After the chemical burn, the animals were randomized into 5 groups. Group 1 did not receive any chemical substance. Group 2 received dimethyl sulfoxide, group 3 received bevacizumab 5 mg/mL, group 4 received dovitinib 5 mg/mL, and group 5 received bevacizumab 5 mg/mL + dovitinib 5 mg/mL topically administered twice daily for 14 days. On the 14th day, slit-lamp examination was performed, and anterior segment photographs were taken. The corneal neovascular area was measured on photographs as the percentage of the cornea's total area using computer imaging analysis. The corneal sections were stained with hematoxylin and eosin for histopathological examination. Results: A statistically significant decrease in the percentage of CNV was found in all treatment groups (group 3, group 4, and group 5) compared with the control group (group 1) (P < 0.01). A statistically significant difference in the percentage of CNV was found among group 3, group 4, and group 5 (P = 0.003). The percentage of CNV in group 4 was significantly higher than that in group 3 and group 5 (P-1 = 0.004; P-2 = 0.006). There was no statistically significant difference in the percentage of CNV between group 3 and group 5 (P = 0.228). Conclusions: Dovitinib is a newly developed multitargeted tyrosine kinase inhibitor. Topical administration of dovitinib effectively inhibited CNV, but this effect of dovitinib was found less than topical bevacizumab.en_US
dc.identifier.citationSahan, B., Ciftci, F., Eyuboglu, S., Yaba, A., Yilmaz, B., & Yalvac, B. I. (2019). Comparison of the effects of dovitinib and bevacizumab on reducing neovascularization in an experimental rat corneal neovascularization model. Cornea, 38(9), 1161-1168.en_US
dc.identifier.doi10.1097/ICO.0000000000002012en_US
dc.identifier.endpage1168en_US
dc.identifier.issn0277-3740en_US
dc.identifier.issn1536-4798en_US
dc.identifier.issue9en_US
dc.identifier.pmid31180924en_US
dc.identifier.scopus2-s2.0-85071349152en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1161en_US
dc.identifier.urihttps://doi.org/10.1097/ICO.0000000000002012en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/566en_US
dc.identifier.volume38en_US
dc.identifier.wosWOS:000484410200025en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEyüboğlu, Siğnemen_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCorneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDovitiniben_US
dc.subjectBevacizumaben_US
dc.subjectCorneal Neovascularizationen_US
dc.subjectTyrosine Kinase Inhibitoren_US
dc.titleComparison of the effects of dovitinib and bevacizumab on reducing neovascularization in an experimental rat corneal neovascularization modelen_US
dc.typeArticleen_US

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