Evaluation of factors affecting lymph node metastasis in clinical stage I-II epithelial ovarian cancer

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dc.contributor.authorErdem, Baki
dc.contributor.authorYuksel, Ilkbal T.
dc.contributor.authorPeker, Nuri
dc.contributor.authorUlukent, Suat C.
dc.contributor.authorAsicioglu, Osman
dc.contributor.authorOzaydin, Ipek Y.
dc.contributor.authorAkbayir, Ozgur
dc.date.accessioned2020-08-30T20:07:51Z
dc.date.available2020-08-30T20:07:51Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractBackground: Systematic lymphadenectomy is useful for accurate staging of early-stage ovarian cancer and has obvious prognostic value. Accurate staging may prevent unnecessary postoperative chemotherapy. The aim of this study was to evaluate the rate of lymph node involvement and factors affecting it in clinically early-stage epithelial ovarian cancer (EOC; stages I, II). Patients and Methods: The study included 163 patients who underwent surgery at our hospital between January 2004 and April 2017 and who were diagnosed with early-stage EOC based on preoperative and intraoperative examination. Patient data were retrospectively analyzed. The rate of lymph node involvement and factors affecting it were analyzed. Results: Of 163 patients, 21 (12.9%) had lymph node metastasis, whereas 16 (16.3%) of 98 patients who underwent comprehensive lymphadenectomy had lymph node metastasis. According to the univariate results for patients undergoing any type of lymphadenectomy, the rate of positive lymph nodes was significantly higher (37.1%) in those with bilateral ovarian involvement (p < 0.001). The rate was significantly higher in patients with positive intraabdominal fluid cytology (25.9%; p < 0.001), serous histology (20.5%; p = 0.02), and grade 3 disease (33.3%; p < 0.001). In multivariate logistic regression analysis, the rate was significantly higher in patients with bilateral adnexal involvement (p = 0.012). The risk of positive lymph nodes was significantly higher in patients with grade 3 disease (p = 0.016). Conclusion: Comprehensive lymphadenectomy increases the detection rate for metastatic lymph nodes in patients with clinically early-stage EOC. The rate of lymph node involvement is significantly higher in grade 3 tumors, serous cytology, bilateral adnexal involvement, and positive intraabdominal fluid cytology. (C) 2018 S. Karger GmbH, Freiburgen_US
dc.identifier.citationErdem, B., Yüksel, I. T., Peker, N., Ulukent, S. C., Aşıcıoğlu, O., Özaydin, I. Y., ... & Akbayir, O. (2018). Evaluation of Factors Affecting Lymph Node Metastasis in Clinical Stage I-II Epithelial Ovarian Cancer. Oncology research and treatment, 41(7-8), 444-448.en_US
dc.identifier.doi10.1159/000488082en_US
dc.identifier.endpage448en_US
dc.identifier.issn2296-5270en_US
dc.identifier.issn2296-5262en_US
dc.identifier.pmid29975960en_US
dc.identifier.scopus2-s2.0-85049882336en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage444en_US
dc.identifier.urihttps://doi.org/10.1159/000488082
dc.identifier.urihttps://hdl.handle.net/20.500.12713/841
dc.identifier.volume41en_US
dc.identifier.wosWOS:000440840200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorPeker, Nurien_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofOncology Research and Treatmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLymph Node Dissectionen_US
dc.subjectLymph Node Metastasesen_US
dc.subjectOvarian Canceren_US
dc.titleEvaluation of factors affecting lymph node metastasis in clinical stage I-II epithelial ovarian canceren_US
dc.typeArticleen_US

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