Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorwosidEngin Ulukaya / K-5792-2018
dc.contributor.authorCoşkun, Demet
dc.contributor.authorErkısa, Merve
dc.contributor.authorUlukaya, Engin
dc.contributor.authorCoşkun, Mehmet Fatih
dc.contributor.authorArı, Ferda
dc.date.accessioned2020-08-30T20:08:07Z
dc.date.available2020-08-30T20:08:07Z
dc.date.issued2017
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractCancer treatment still requires new compounds to be discovered. Chalcone and its derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran substituted chalcone derivatives was synthesized by the base-catalyzed Claisen-Schmidt reaction of the 1-(7-ethoxy-1-benzofuran-2-yl) ethanone with different aromatic aldehydes to yield 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives 3a-j. The derivatives were characterized by elemental analysis, FT-IR, H-1 NMR and C-13 NMR spectroscopy techniques. The anti-growth effect of chalcone compounds was tested in breast cancer (MCF-7), non-small cell lung cancer (A549) and prostate cancer (PC-3) cell lines by the SRB and ATP cell viability assays. Apoptosis was detected by mitochondrial membrane potential, Annexin V staining and caspase 3/7 activity. Formation of reactive oxygen species was determined by DCFDA. The results revealed that chalcone derivatives have anticancer activity with especially chalcone derivative 3a showing cytotoxic effects on cancer cells. In addition, chalcone derivative 3a induced apoptosis through caspase dependent pathways in prostate, lung and breast cancer cells. (C) 2017 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipFirat UniversityFirat University [FF.16.15]en_US
dc.description.sponsorshipThe authors thank Firat University for financial support of this work. Project Number: FF.16.15.en_US
dc.identifier.citationCoskun, D., Erkisa, M., Ulukaya, E., Coskun, M. F., & Ari, F. (2017). Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: Synthesis, characterization and anticancer activity. European Journal of Medicinal Chemistry, 136, 212–222. https://doi.org/10.1016/j.ejmech.2017.05.017en_US
dc.identifier.doi10.1016/j.ejmech.2017.05.017en_US
dc.identifier.endpage222en_US
dc.identifier.issn0223-5234en_US
dc.identifier.issn1768-3254en_US
dc.identifier.pmid28494257en_US
dc.identifier.scopus2-s2.0-85018440526en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage212en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2017.05.017
dc.identifier.urihttps://hdl.handle.net/20.500.12713/886
dc.identifier.volume136en_US
dc.identifier.wosWOS:000403993500017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUlukaya, Enginen_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofEuropean Journal of Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzofuranen_US
dc.subjectChalconeen_US
dc.subjectCytotoxicityen_US
dc.subjectAnticancer Activityen_US
dc.subjectApoptosisen_US
dc.titleNovel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activityen_US
dc.typeArticleen_US

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