Preparation and characterization of graphene-based 3D biohybrid hydrogel bioink for peripheral neuroengineering

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dc.authoridHakan Darıcı / 0000-0001-9393-554Xen_US
dc.authoridAslı Pınar Zorba Yıldız / 0000-0001-6854-9890en_US
dc.authoridErdal Karaöz / 0000-0002-9992-833Xen_US
dc.authorscopusidAslı Pınar Zorba Yıldız / 57626992600
dc.authorscopusidHakan Darıcı / 22333489600
dc.authorscopusidErdal Karaöz / 7003448087
dc.authorwosidHakan Darıcı / AAG-4316-2019en_US
dc.authorwosidAslı Pınar Zorba Yıldız / L-6429-2018en_US
dc.authorwosidErdal Karaöz / AAO-1470-2020en_US
dc.contributor.authorZorba Yıldız, Aslı Pınar
dc.contributor.authorDarıcı, Hakan
dc.contributor.authorYavuz, Burçak
dc.contributor.authorAbamor, Emrah Şefik
dc.contributor.authorÖzdemir, Ceren
dc.contributor.authorYasin, Müge Elif
dc.contributor.authorBağırova, Melahat
dc.contributor.authorAllahverdiyev, Adil
dc.contributor.authorKaraöz, Erdal
dc.date.accessioned2022-06-07T07:28:08Z
dc.date.available2022-06-07T07:28:08Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Laboratuvar Teknikleri Bölümüen_US
dc.description.abstractPeripheral neuropathies can occur as a result of axonal damage, and occasionally due to demyelinating diseases. Peripheral nerve damage is a global problem that occurs in 1.5%-5% of emergency patients and may lead to significant job losses. Today, tissue engineering-based approaches, consisting of scaffolds, appropriate cell lines, and biosignals, have become more applicable with the development of three-dimensional (3D) bioprinting technologies. The combination of various hydrogel biomaterials with stem cells, exosomes, or bio-signaling molecules is frequently studied to overcome the existing problems in peripheral nerve regeneration. Accordingly, the production of injectable systems, such as hydrogels, or implantable conduit structures formed by various bioprinting methods has gained importance in peripheral neuro-engineering. Under normal conditions, stem cells are the regenerative cells of the body, and their number and functions do not decrease with time to protect their populations; these are not specialized cells but can differentiate upon appropriate stimulation in response to injury. The stem cell system is under the influence of its microenvironment, called the stem cell niche. In peripheral nerve injuries, especially in neurotmesis, this microenvironment cannot be fully rescued even after surgically binding severed nerve endings together. The composite biomaterials and combined cellular therapies approach increases the functionality and applicability of materials in terms of various properties such as biodegradability, biocompatibility, and processability. Accordingly, this study aims to demonstrate the preparation and use of graphene-based biohybrid hydrogel patterning and to examine the differentiation efficiency of stem cells into nerve cells, which can be an effective solution in nerve regeneration.en_US
dc.identifier.citationZorba Yildiz AP, Darici H, Yavuz B, Abamor ES, Ozdemir C, Yasin ME, Bagirova M, Allahverdiyev A, Karaoz E. Preparation and Characterization of Graphene-Based 3D Biohybrid Hydrogel Bioink for Peripheral Neuroengineering. J Vis Exp. 2022 May 16;(183). doi: 10.3791/63622. PMID: 35635451.en_US
dc.identifier.doi10.3791/63622en_US
dc.identifier.issn1940-087Xen_US
dc.identifier.pmid35635451en_US
dc.identifier.scopus2-s2.0-85131222251en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.3791/63622
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2803
dc.identifier.volume168en_US
dc.identifier.wosWOS:000810986100003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaraöz, Erdal
dc.institutionauthorZorba Yıldız, Aslı Pınar
dc.institutionauthorDarıcı, Hakan
dc.language.isoenen_US
dc.publisherJoveen_US
dc.relation.ispartofJournal of Visualized Experimenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePreparation and characterization of graphene-based 3D biohybrid hydrogel bioink for peripheral neuroengineeringen_US
dc.typeVideoen_US

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