COVID 19 and febrile neutropenia: Case report and systematic review

dc.authoridAhmet Dilek / 0000-0001-7111-2438en_US
dc.authorscopusidAhmet Dilek / 26028752200
dc.authorwosidAhmet Dilek / AAV-7176-2021
dc.contributor.authorKaya, Taner
dc.contributor.authorDilek, Ahmet
dc.contributor.authorÖzaras, Reşat
dc.contributor.authorBalçık, Özlem Şahin
dc.contributor.authorLeblebicioğu, Hakan
dc.date.accessioned2022-03-23T05:53:06Z
dc.date.available2022-03-23T05:53:06Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractObjectives: In pandemic conditions, patients with febrile neutropenia are also at risk of COVID-19. Aim of this systematic review is to evaluate COVID-19 cases presented with febrile neutropenia and provide information regarding incidence, clinical course and prognosis. Methods: We systematically searched on COVID-19 and febrile neutropenia cases in PubMed, SCOPUS and Web of Science. Results: A total of 19 febrile neutropenic patients were analyzed. A male predominance was noted. Eleven cases had hematological malignancies. Fourteen of the cases were previously received chemotherapy. Five patients had severe neutropenia: 3 had hematologic cancer and none died. 17 (89.5%) cases have pulmonary involvement and seven of them had severe disease with acute respiratory distress syndrome (ARDS). Three cases with ARDS were died. 12 of them received G-CSF for treatment. Five cases were developed respiratory failure after G-CSF use. Overall mortality was 15.8%, while death was not observed in patients without malignancy and solid organ tumors, the mortality rate was 27% in cases with hematological malignancies. Conclusion: In ongoing pandemic, febrile neutropenic patients should be precisely evaluated for COVID-19 disease. It should be remembered that there may not be typical signs and symptoms and laboratory findings of COVID-19 disease because of the immunosuppression. © 2022 Elsevier Ltden_US
dc.identifier.citationKaya, T., Dilek, A., Ozaras, R., Balcik, O. S., & Leblebicioglu, H. (2022). COVID 19 and febrile neutropenia: Case report and systematic review. Travel Medicine and Infectious Disease, 47 doi:10.1016/j.tmaid.2022.102305en_US
dc.identifier.doi10.1016/j.tmaid.2022.102305en_US
dc.identifier.issn1477-8939en_US
dc.identifier.scopus2-s2.0-85126086196en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.tmaid.2022.102305
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2571
dc.identifier.volume47en_US
dc.identifier.wosWOS:000819918900014en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDilek, Ahmet
dc.language.isoenen_US
dc.publisherElsevier Inc.en_US
dc.relation.ispartofTravel Medicine and Infectious Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCOVID 19 and febrile neutropenia: Case report and systematic reviewen_US
dc.typeReview Articleen_US

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