Characterization of hand clenching in human sensorimotor cortex using high-, and ultra-high frequency band modulations of electrocorticogram

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dc.authoridSacit Karamürsel / 0000-0002-7534-9392
dc.authorscopusidSacit Karamürsel / 7004361830
dc.authorwosidSacit Karamürsel / O-9371-2019
dc.contributor.authorJiang, Tianxiao
dc.contributor.authorLiu, Su
dc.contributor.authorPellizzer, Giuseppe
dc.contributor.authorAydöşeli, Aydın
dc.contributor.authorKaramürsel, Sacit
dc.contributor.authorSabancı, Pulat A.
dc.contributor.authorİnce, Nuri F.
dc.date.accessioned2020-08-30T20:07:42Z
dc.date.available2020-08-30T20:07:42Z
dc.date.issued2018
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractFunctional mapping of eloquent cortex before the resection of a tumor is a critical procedure for optimizing survival and quality of life. In order to locate the hand area of the motor cortex in two patients with low-grade gliomas (LGG), we recorded electrocorticogram (ECoG) from a 113 channel hybrid high-density grid (64 large contacts with diameter of 2.7 mm and 49 small contacts with diameter of 1 mm) while they executed hand clenching movements. We investigated the spatio-spectral characteristics of the neural oscillatory activity and observed that, in both patients, the hand movements were consistently associated with a wide spread power decrease in the low frequency band (LFB: 8-32 Hz) and a more localized power increase in the high frequency band (HFB: 60-280 Hz) within the sensorimotor region. Importantly, we observed significant power increase in the ultra-high frequency band (UFB: 300-800 Hz) during hand movements of both patients within a restricted cortical region close to the central sulcus, and the motor cortical " hand knob." Among all frequency bands we studied, the UFB modulations were closest to the central sulcus and direct cortical stimulation (DCS) positive site. Both HFB and UFB modulations exhibited different timing characteristics at different locations. Power increase in HFB and UFB starting before movement onset was observedmostly at the anterior part of the activated cortical region. In addition, the spatial patterns in HFB and UFB indicated a probable postcentral shift of the hand motor function in one of the patients. We also compared the task related subband modulations captured by the small and large contacts in our hybrid grid. We did not find any significant difference in terms of band power changes. This study shows initial evidence that event-driven neural oscillatory activity recorded from ECoG can reach up to 800 Hz. The spatial distribution of UFB oscillations was found to be more focalized and closer to the central sulcus compared to LFB and HFB. More studies are needed to characterize further the functional significance of UFB relative to LFB and HFB.en_US
dc.identifier.citationJiang, T., Liu, S., Pellizzer, G., Aydoseli, A., Karamursel, S., Sabanci, P. A., ... & Ince, N. F. (2018). Characterization of hand clenching in human sensorimotor cortex using high-, and ultra-high frequency band modulations of electrocorticogram. Frontiers in Neuroscience, 12, 110.en_US
dc.identifier.doi10.3389/fnins.2018.00110en_US
dc.identifier.issn1662-453Xen_US
dc.identifier.pmid29535603en_US
dc.identifier.scopus2-s2.0-85050877265en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3389/fnins.2018.00110
dc.identifier.urihttps://hdl.handle.net/20.500.12713/816
dc.identifier.volume12en_US
dc.identifier.wosWOS:000426213700001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKaramürsel, Saciten_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHybrid High-Density Griden_US
dc.subjectEcogen_US
dc.subjectUltra-High Frequency Banden_US
dc.subjectHand Movementen_US
dc.subjectSensorimotoren_US
dc.subjectPostcentral Shiften_US
dc.titleCharacterization of hand clenching in human sensorimotor cortex using high-, and ultra-high frequency band modulations of electrocorticogramen_US
dc.typeArticleen_US

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