The role of resolvin D1 in indicating chronic inflammation and axonal damage in bipolar disorder: a comparative study of manic and depressive episodes

Basit Öğe Kaydı
dc.authorscopusidRefik Cihnioğlu / 57200314716
dc.authorwosidRefik Cihnioğlu / CJY-9413-2022
dc.contributor.authorKök Kendirlioğlu, Burcu
dc.contributor.authorYüksel Öksüz, Özge
dc.contributor.authorKalelioğlu, Tevfik
dc.contributor.authorSözen, Şule
dc.contributor.authorÜnalan Özperçin, Pelin
dc.contributor.authorCihnioğlu, Refik
dc.date.accessioned2025-04-17T08:09:15Z
dc.date.available2025-04-17T08:09:15Z
dc.date.issued2025
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, İSÜ Hastaneleri
dc.description.abstractIntroduction: Bipolar disorder (BD) is a chronic disorder associated with significant psychiatric morbidity and disability. Recent research has linked inflammatory processes to the pathology of BD. Resolvin D1 (RvD1), an anti-inflammatory molecule derived from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been shown to inhibit apoptosis and neuroinflammation, and promote neurogenesis. This study aims to determine changes in serum RvD1 levels between acute episode and euthymic periods in patients with BD and their association with inflammatory and metabolic syndrome (MetS) parameters. Methods: This prospective clinical study was conducted with patients diagnosed with BD-I according to SCID-5. Patients whose serum RvD1 levels were assessed during manic and depressive episodes in the previous study were invited to return to the study after at least 8 weeks, when they had reached the euthymic period. Blood samples for RvD1, C-reactive protein (CRP), and hemogram tests were collected during both acute episodes and remission periods. Results: The study included 32 patients in manic episodes, 27 in depressive episodes, and 41 healthy controls, with no significant age difference amongthe groups. RvD1 levels decreased significantly from manic episodes to complete remission period (p=0.017, z=-2.391) during follow-up. The decrease from depression to remission was not statistically significant. Serum RvD1 levels in patients with depressive episodes in remission remained high in the control group (p=0.581, z=-0.553). During the followup period, white blood cell (p=0.009, z=-2.606) and neutrophil (p=0.007, z=-2.693) in mania period and CRP values in depression period (p=0.004, z=-2.880) were found to have decreased statistically. Conclusions: The study indicates that serum RvD1 levels are elevated during manic and depressive episodes in BD patients compared to healthy controls and decrease significantly during the remission period in patients with manic episode. We propose the potential utility of RvD1 as a diagnostic marker for identifying manic and depressive states. We can assume that there is an inflammatory process in BD in which RvD1 also plays a role. Further research is needed to explore the therapeutic potential of targeting RvD1 pathways in BD treatment.
dc.identifier.citationKendirlioğlu, B. K., Öksüz, Ö. Y., Kalelioğlu, T., Sözen, Ş., Özperçin, P. Ü., Cihnioğlu, R., & Karamustafalıoğlu, N. (2025). The Role of Resolvin D1 in Indicating Chronic Inflammation and Axonal Damage in Bipolar Disorder: A Comparative Study of Manic and Depressive Episodes. Archives of Neuropsychiatry, 62(1), 3.
dc.identifier.doi10.29399/npa.28891
dc.identifier.endpage10
dc.identifier.issn1300-0667
dc.identifier.issn1309-4866
dc.identifier.issue1
dc.identifier.pmid40046207
dc.identifier.scopus2-s2.0-86000291166
dc.identifier.scopusqualityQ3
dc.identifier.startpage3
dc.identifier.urihttp://dx.doi.org/10.29399/npa.28891
dc.identifier.urihttps://hdl.handle.net/20.500.12713/6147
dc.identifier.volume62
dc.identifier.wosWOS:001436755800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorCihnioğlu, Refik
dc.institutionauthoridRefik Cihnioğlu / 0009-0005-0495-7904
dc.language.isoen
dc.publisherTurkish neuropsychiatric society
dc.relation.ispartofNoropsikiyatri arşivi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAxonal Degeneration
dc.subjectBipolar Disorder
dc.subjectMetabolic Syndrome
dc.subjectNeuroinflammation
dc.subjectResolvin D1
dc.titleThe role of resolvin D1 in indicating chronic inflammation and axonal damage in bipolar disorder: a comparative study of manic and depressive episodes
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
28891-erkenbaski-en-99197.pdf
Boyut:
398.89 KB
Biçim:
Adobe Portable Document Format
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.17 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

İSÜ Hastaneleri Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu