Quantitative evaluation of hepatic steatosis using attenuation imaging in a pediatric population: a prospective study

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dc.authoridBULAKCI, MESUT/0000-0003-0993-6465
dc.authoridTuğrul Aksakal, Melike Zeynep/0000-0001-5394-1566
dc.authoridErcan, Celal Caner/0000-0003-2922-5847
dc.authorwosidBULAKCI, MESUT/AAT-1558-2020
dc.authorwosidTuğrul Aksakal, Melike Zeynep/GYU-2926-2022
dc.contributor.authorBulakci, Mesut
dc.contributor.authorErcan, Celal Caner
dc.contributor.authorKarapinar, Edanur
dc.contributor.authorAksakal, Melike Zeynep Tugrul
dc.contributor.authorAliyev, Shamil
dc.contributor.authorBicen, Fuat
dc.contributor.authorSahin, Aylin Yetim
dc.date.accessioned2024-05-19T14:39:11Z
dc.date.available2024-05-19T14:39:11Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractBackgroundObesity and fatty-liver disease are increasingly common in children. Hepatic steatosis is becoming the most common cause of chronic liver disease during childhood. There is a need for noninvasive imaging methods that are easily accessible, safe and do not require sedation in the diagnosis and follow-up of the disease.ObjectiveIn this study, the diagnostic role of ultrasound attenuation imaging (ATI) in the detection and staging of fatty liver in the pediatric age group was investigated using the magnetic resonance imaging (MRI)-proton density fat fraction as the reference.Materials and methodsA total of 140 children with both ATI and MRI constituted the study group. Fatty liver was classified as mild (S1, defined as >= 5% steatosis), moderate (S2, defined as >= 10% steatosis), or severe (S3, defined as >= 20% steatosis) according to MRI-proton density fat fraction values. MRI studies were performed on the same 1.5-tesla (T) MR device without sedation and contrast agent. Ultrasound examinations were performed independently by two radiology residents blinded to the MRI data.ResultsWhile no steatosis was detected in half of the cases, S1 steatosis was found in 31 patients (22.1%), S2 in 29 patients (20.7%) and S3 in 10 patients (7.1%). A strong correlation was found between attenuation coefficient and MRI-proton density fat fraction values (r = 0.88, 95% CI 0.84-0.92; P < 0.001). The area under the receiver operating characteristic curve values of ATI were calculated as 0.944 for S > 0, 0.976 for S > 1 and 0.970 for S > 2, based on 0.65, 0.74 and 0.91 dB/cm/MHz cut-off values, respectively. The intraclass correlation coefficient values for the inter-observer agreement and test-retest reproducibility were calculated as 0.90 and 0.91, respectively.ConclusionUltrasound attenuation imaging is a promising noninvasive method for the quantitative evaluation of fatty liver disease.en_US
dc.identifier.doi10.1007/s00247-023-05615-8
dc.identifier.endpage1639en_US
dc.identifier.issn0301-0449
dc.identifier.issn1432-1998
dc.identifier.issue8en_US
dc.identifier.pmid36881143en_US
dc.identifier.scopus2-s2.0-85149419979en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1629en_US
dc.identifier.urihttps://doi.org10.1007/s00247-023-05615-8
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4722
dc.identifier.volume53en_US
dc.identifier.wosWOS:000945320600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofPediatric Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAttenuation Imagingen_US
dc.subjectChildrenen_US
dc.subjectLiver Steatosisen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.subjectNon-Alcoholic Fatty Liveren_US
dc.subjectUltrasonographyen_US
dc.titleQuantitative evaluation of hepatic steatosis using attenuation imaging in a pediatric population: a prospective studyen_US
dc.typeArticleen_US

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