Advances and Challenges in Interventional Immuno-Oncology Locoregional Therapies
Küçük Resim Yok
Tarih
2024
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Interventional immuno-oncology is making strides in locoregional therapies to address complex tumor microenvironments. Long-standing interventional radiology cancer therapies, such as tumor ablation and embolization, are being recharacterized in the context of immunotherapy. Intratumoral injections, such as those of genetically engineered or unaltered viruses, and the delivery of immune cells, antibodies, proteins, or cytokines into targeted tumors, along with advancements in delivery techniques, have produced promising results in preliminary studies, indicating their antitumor effectiveness. Emerging strategies using DNA scaffolding, polysaccharides, glycan, chitosan, and natural products are also showing promise in targeted cancer therapy. The future of interventional immuno-oncology lies in personalized immunotherapies that capitalize on individual immune profiles and tumor characteristics, along with the exploration of combination therapies. This study will review various interventional immuno-oncology strategies and emerging technologies to enhance delivery of therapeutics and response to immunotherapy.
Açıklama
Anahtar Kelimeler
Hepatocellular-Carcinoma, Intralesional Pv-10, Cell Immunotherapy, Oncolytic Viruses, Cancer, Blockade, Ablation, Cryoablation, Barriers, Delivery
Kaynak
Journal of Vascular and Interventional Radiology
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
35
Sayı
2
