Indirect evaluation of amyloid deposition by ultrasonography and its relationship with MEFV gene mutation in FMF patients

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dc.authoridGürkan Yılmaz / 0000-0002-5472-2530en_US
dc.authorscopusidGürkan Yılmaz / 57192691460
dc.authorwosidGürkan Yılmaz / EGQ-1542-2022
dc.contributor.authorUrfalı, Mine
dc.contributor.authorYılmaz, Gürkan
dc.contributor.authorÖzkul, Bahattin
dc.contributor.authorUrfalı, Furkan Ertürk
dc.date.accessioned2022-12-30T08:23:51Z
dc.date.available2022-12-30T08:23:51Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractObjectiveThe most significant complication in familial mediterranean fever (FMF) patients is dysfunction and organ failure developing depending on amyloid deposition in organs. The golden standard for showing amyloid deposition is the biopsy; however, tissue stiffness was examined by shear wave elastography as a non-invasive method in a restricted number of studies conducted, and it is considered that amyloid deposition can be shown indirectly. In our study, we aimed to indirectly evaluate amyloid deposition in organs with Shear wave and Doppler ultrasonography and to reveal its relationship with MEFV gene mutation analysis. Method42 FMF patients with normal thyroid and renal function tests and 35 participants with no FMF symptoms were included in our study. FMF patients were grouped depending on their MEFV mutation analyses. Thyroid, salivary glands, and renal parenchymal tissue stiffness were evaluated by shear wave elastography. Thyroidal artery and both renal artery resistances were evaluated by Doppler ultrasonography. ResultsBoth parotis gland, thyroid and renal parenchymal stiffness and arterial vascular resistances in the patient group were found higher than the control group. A significant difference was not found in any parameters in classification based on gender. Tissue stiffness and vascular resistance values in the patient group with M694V homozygote mutation were found statistically significantly higher than the other mutation groups (p < 0.001). ConclusionOur study shows that identifying genetic mutation type in FMF patients will help determine possibly amyloidosis risk. Imaging of tissue stiffness by shear wave elastography and evaluation of vascular resistance by Doppler can be useful for routine screening of those patients.en_US
dc.identifier.citationUrfali, M., Yilmaz, G., Özkul, B., & Urfali, F. E. (2022). Indirect evaluation of amyloid deposition by ultrasonography and its relationship with MEFV gene mutation in FMF patients. Journal of Clinical Ultrasound.en_US
dc.identifier.doi10.1002/jcu.23409en_US
dc.identifier.issn0091-2751en_US
dc.identifier.issn1097-0096en_US
dc.identifier.scopus2-s2.0-85143203844en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttp://dx.doi.org/10.1002/jcu.23409
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3787
dc.identifier.wosWOS:000892554300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYılmaz, Gürkan
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF CLINICAL ULTRASOUNDen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmi?loi?dosi?sen_US
dc.subjectElastographyen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectMEFV Geneen_US
dc.titleIndirect evaluation of amyloid deposition by ultrasonography and its relationship with MEFV gene mutation in FMF patientsen_US
dc.typeArticleen_US

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