Soluble Receptor for Advanced Glycation End Products (sRAGE) Level and Its Prognostic Significance in Children with Acute Lymphoblastic Leukemia

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dc.authoridCelik, Binnaz tekatli/0000-0001-8852-0067
dc.authorwosidCelik, Binnaz tekatli/JLL-1388-2023
dc.contributor.authorOzkan, Busra
dc.contributor.authorAltuner Torun, Yasemin
dc.contributor.authorKarakukcu, Cigdem
dc.contributor.authorCelik, Binnaz
dc.date.accessioned2024-05-19T14:38:57Z
dc.date.available2024-05-19T14:38:57Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractAcute lymphoblastic leukemias are the most common malignancies in childhood. Although its etiology is still unclear, it is thought that disorders in oxidative stress metabolism may contribute to leukemogenesis. Advanced glycation end products (AGEs) are formed as a result of the non-enzymatic binding of sugars to biomolecules. Oxidation reactions are triggered through AGE-Receptor (RAGE) interaction, resulting in the formation of reactive oxygen species. These can play crucial roles in cancer pathogenesis and leukemogenesis. It is thought that sRAGE (soluble RAGE) is the end product of glycation and circulates freely in the circulation by binding to RAGE ligands. We investigate novel leukemia biomarkers and focus on soluble RAGE (sRAGE) for acute lymphoblastic leukemia (ALL) diagnosis and prognosis. Thirty children (1-17 years) diagnosed with ALL were included in the study. Patients were divided into standard, medium, and high risk groups according to the Berlin-Frankfurt-Munster (BFM) treatment protocol. Patients were evaluated twice; at the time of diagnosis and at the sixth month of remission. sRAGE and blood parameters were compared with healthy controls (n = 30, 1-17 years). The sRAGE levels in ALL patients at diagnosis (138.7 +/- 177.3 pg/mL) were found to be significantly higher than they were during the sixth month of remission (17.6 +/- 21.1 pg/mL) and in healthy controls (22.2 +/- 23.7 pg/mL). The cut-off value of the sRAGE level for the diagnosis of ALL was found to be 45 pg/mL in ROC analysis (sensitivity: 73.3%, specificity: 86.7%, AUC: 0.681). At the same time, the sRAGE level was found to be significantly higher in T-ALL patients (490.9 +/- 236.9 pg/mL) than in B-ALL patients (84.5 +/- 82.7 pg/mL). No significant difference was found in terms of the sRAGE level between standard (45.8 +/- 33.1 pg/mL), medium (212 +/- 222.1 pg/mL), and high (143.9 +/- 111.5 pg/mL) risk group ALL patients classified according to the BFM protocol. Despite the fact that this was a small, single-center study, our findings highlight the potential use of sRAGE as a biomarker for diagnosing ALL and assessing response to treatment.en_US
dc.identifier.doi10.3390/children11020176
dc.identifier.issn2227-9067
dc.identifier.issue2en_US
dc.identifier.pmid38397288en_US
dc.identifier.scopus2-s2.0-85185925581en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.3390/children11020176
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4658
dc.identifier.volume11en_US
dc.identifier.wosWOS:001171935400001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofChildren-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAllen_US
dc.subjectSrageen_US
dc.subjectDiagnosisen_US
dc.subjectChildrenen_US
dc.titleSoluble Receptor for Advanced Glycation End Products (sRAGE) Level and Its Prognostic Significance in Children with Acute Lymphoblastic Leukemiaen_US
dc.typeArticleen_US

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