Evidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humans

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dc.authoridEngin Ulukaya / 0000-0003-4875-5472en_US
dc.authoridElif Sedef Develi / 0000-0001-6696-7001
dc.authoridDidem Karakaş Zeybek / 0000-0002-3781-6834
dc.authorscopusidEngin Ulukaya / 6602927353
dc.authorscopusidDidem Karakaş Zeybek / 56422040600
dc.authorwosidEngin Ulukaya / K-5792-2018en_US
dc.authorwosidDidem Karakaş Zeybek / L-6682-2018en_US
dc.authorwosidElif Sedef Develi / GMD-9509-2022en_US
dc.contributor.authorTurna, Özge
dc.contributor.authorÜvez, Ayça
dc.contributor.authorBaykal, Aslıhan
dc.contributor.authorDeveli, Elif Sedef
dc.contributor.authorDıramalı, Murat
dc.contributor.authorSönmez, Kıvılcım
dc.contributor.authorKarakaş, Didem
dc.contributor.authorKaşıkçı, Güven
dc.contributor.authorArmutak, Elif İlkay
dc.contributor.authorUlukaya, Engin
dc.date.accessioned2022-05-20T11:29:06Z
dc.date.available2022-05-20T11:29:06Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractTumors are formed by various clones developed over a long time. This gives rise to a heterogeneous nature. This heterogeneity is the hardest challenge in the treatment of cancers because it is the main reason for drug resistance. This is a well-known fact in human cancer. Therefore, we have reasoned that if the tumor heterogeneity in canine mammary gland tumors (CMGTs) could be shown by an ex vivo assay, which will be used first time in veterinary oncology practice, this could be used further in clinics. To achieve this, twenty-six patients were included in the study. Tumor tissues were obtained from animals during routine surgery. Tumor cells were isolated and seeded ex vivo. The cells were exposed to anticancer drugs that are clinically used. Seven days after the treatment, chemosensitivity has luminometrically been assayed by ATP-tumor chemosensitivity assay (ATP-TCA). It has clearly been shown that all the tumor tissues have responded to treatment differently, implying that heterogeneity exists in mammary tumors. There has also been found that there was a weak to moderate statistically significant correlation between tumor size and drug index. However, there has been no correlation between drug index and metastasis to lymph nodes. Hyperplasic areas had relatively higher PCNA values. The results of our study demonstrate the heterogeneity in responses to in vitro drugs. Clinical trials based on test results and follow-up studies with large numbers of animals are needed to prove that such chemotherapeutic activity assessment tests can be clinically useful in predicting drug responses in CMGTs.en_US
dc.identifier.citationTurna O, Uvez A, Baykal A, Sedef Develi E, Diramali M, Sonmez K, Karakas D, Kasikci G, Armutak EI, Ulukaya E. Evidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humans. Vet Res Commun. 2022 May 16. doi: 10.1007/s11259-022-09934-3. Epub ahead of print. PMID: 35570257.en_US
dc.identifier.doi10.1007/s11259-022-09934-3en_US
dc.identifier.issn0165-7380en_US
dc.identifier.pmid35570257en_US
dc.identifier.scopus2-s2.0-85130110242en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttp://doi.org/10.1007/s11259-022-09934-3
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2686
dc.identifier.wosWOS:000795759200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDeveli, Elif Sedef
dc.institutionauthorKarakaş Zeybek, Didem
dc.institutionauthorUlukaya, Engin
dc.language.isoenen_US
dc.publisherNCI CPTAC Assay Portalen_US
dc.relation.ispartofVeterinary Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCanineen_US
dc.subjectChemosensitivityen_US
dc.subjectChemotherapyen_US
dc.subjectMammary Tumoren_US
dc.titleEvidence for heterogeneity in response to treatment in mammary tumors of dogs as happens in humansen_US
dc.typeArticleen_US

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