Dysregulation of MS4A3 and PRDX5 gene expression in multiple myeloma patients

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dc.authoridMelda Sarıman / 0000-0003-0898-529X
dc.authorscopusidMelda Sarıman / 57191042731
dc.authorwosidMelda Sarıman / ABB-8877-2021
dc.contributor.authorSuer, İlknur
dc.contributor.authorAday, Aynur
dc.contributor.authorSarıman, Melda
dc.contributor.authorAyer, Mesut
dc.contributor.authorHindilerden, İpek Yonal
dc.contributor.authorEkmekçi, Sema Sırma
dc.contributor.authorAbacı, Neslihan
dc.contributor.authorPalanduz, Şükrü
dc.date.accessioned2021-10-25T14:19:11Z
dc.date.available2021-10-25T14:19:11Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesien_US
dc.description.abstractMultiple myeloma (MM) is a disease in which plasma cells increase clonally. We aimed to investigate the comparison of our transcriptome data in MM, MGUS (Monoclonal gammopathy of undetermined significance) and control groups in our research. Analysis of transcriptome data revealed that CD74, FUS, MS4A3, PTPN6, PRDX5 and UNC45B genes were significantly different in the MM group compared to control group. Pathway analyzes of these genes have shown that they are associated with certain pathways such as the cellular response and immunological system. In this study, we aimed to examine the expression levels of these genes among the MM (n=50), MGUS (n=15) and control (n=14) groups using the Quantitative Real-Time Polymerase Chain Reaction. According to the consequence of the study, it was determined that MS4A3 gene expression decreased significantly in the MM patient group compared to MGUS and control group, while PRDX5 gene expression was significantly increased. Also ROC (Receiver Operating Characteristic) analysis showed that MS4A3 gene has a significant diagnostic power between MM and MGUS group (area=0.727; p=0.008). Since multiple myeloma is more common in men than in women, it was statistically evaluated whether there is no difference in gene expression between women and men. However, it was determined that there was no statistically significant difference between the groups. As a result, the MS4A3 and PRDX5 genes, which are important in various diseases such as cancer, may shed light on new treatment options for MM disease.en_US
dc.identifier.citationIlknur, S. U. E. R., Aynur, A. D. A. Y., SARIMAN, M., Mesut, A. Y. E. R., HINDILERDEN, I. Y., EKMEKCI, S. S., ... & OZTURK, S. Dysregulation of MS4A3 and PRDX5 Gene Expression in Multiple Myeloma Patients. International Journal of Hematology and Oncology, 31(4), 205-213.en_US
dc.identifier.doi10.4999/uhod.215420en_US
dc.identifier.endpage213en_US
dc.identifier.issn1306-133Xen_US
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85117863852en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage205en_US
dc.identifier.trdizinid1178840en_US
dc.identifier.urihttps://doi.org/10.4999/uhod.215420
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2179
dc.identifier.volume31en_US
dc.identifier.wosWOS:000708227600002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorSarıman, Melda
dc.language.isoenen_US
dc.publisherAKAD DOKTORLAR YAYINEVIen_US
dc.relation.ispartofUHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTranscriptomeen_US
dc.subjectMultiple Myelomaen_US
dc.subjectGene Expressionen_US
dc.subjectMS4A3en_US
dc.subjectPRDX5en_US
dc.titleDysregulation of MS4A3 and PRDX5 gene expression in multiple myeloma patientsen_US
dc.typeArticleen_US

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