The effects of different vasovasostomy techniques on motility of vas deferens (vas motility following vasovasostomy)

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dc.authoridpampal, arzu/0000-0002-3889-990X
dc.authoridOzturk Fincan, Gokce Sevim/0000-0003-1633-3320
dc.authorwosidpampal, arzu/ABU-4345-2022
dc.contributor.authorPampal, Arzu
dc.contributor.authorFincan, Gokce Sevim Ozturk
dc.contributor.authorOzen, Ibrahim Onur
dc.contributor.authorIsli, Fatma
dc.contributor.authorYildirim, Seniz
dc.contributor.authorErcan, Sevim
dc.contributor.authorSarioglu, Yusuf
dc.date.accessioned2024-05-19T14:41:08Z
dc.date.available2024-05-19T14:41:08Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPurpose Vasovasostomy is used to correct vas deferens (VD) transections encountered during surgery or to reverse sterilization vasectomies. Achieving vasal patency is the primary goal and the success is assessed on various factors including VD patency, flow rates, and pregnancy rates. While preserving vas motility is not a major concern in surgical practice, it is worth noting that VD has peristaltic activity which plays crucial role during ejaculation. Any disruption in its motility could potentially lead to negative outcomes in the future. We conducted an experimental study to assess vas motility changes following vasovasostomy.Methods The study was approved by Gazi University, Animals Ethic Committee. Twenty-four rats were allocated to four groups. Left-sided VD was harvested in control group (Gr1). The rest of the animals were subjected to transection of VD. Gr2 and 3 underwent microscopic and macroscopic anastomosis, respectively, while Gr4 underwent vasal approximation. After 12 weeks, all left-sided VD were resected, electrical field stimulation (EFS) and exogenous drugs were applied to induce contractions. Statistical analyses were performed and p value < 0.05 was regarded as statistically significant.Results The first and second phases of EFS-induced contractile responses(CR) increased for Gr3 and decreased for Gr4 at submaximal and maximal frequencies. An increase only at maximal frequency for second phase EFS-induced CR was encountered for Gr2. alpha-beta-methylene-ATP-induced CR decreased for Gr3 and 4. Noradrenaline-induced CR increased for Gr2, and 3 and decreased for Gr4.Conclusion The results suggest that vasovasostomy performed using a surgical technique that minimizes disruption or damage to VD may have a favorable impact on motility.en_US
dc.identifier.doi10.1007/s00345-023-04668-6
dc.identifier.endpage3800en_US
dc.identifier.issn0724-4983
dc.identifier.issn1433-8726
dc.identifier.issue12en_US
dc.identifier.pmid37880539en_US
dc.identifier.scopus2-s2.0-85174742177en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage3795en_US
dc.identifier.urihttps://doi.org10.1007/s00345-023-04668-6
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5067
dc.identifier.volume41en_US
dc.identifier.wosWOS:001089096500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofWorld Journal of Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectEfs (Electrical Field Stimulation)en_US
dc.subjectVas Anastomosisen_US
dc.subjectVas Approximationen_US
dc.subjectVas Deferens Motilityen_US
dc.subjectVasovasostomyen_US
dc.titleThe effects of different vasovasostomy techniques on motility of vas deferens (vas motility following vasovasostomy)en_US
dc.typeArticleen_US

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