Relationship of negative symptom severity with cognitive symptoms and functioning in subjects at ultra-high risk for psychosis

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dc.authoridHandan Noyan /0000-0003-0060-6291
dc.authorscopusidHandan Noyan /56209007800
dc.authorwosidHandan Noyan /AAP-8613-2020
dc.contributor.authorUcok, Alp
dc.contributor.authorDirek, Nese
dc.contributor.authorKaya, Hatice
dc.contributor.authorCaglar, Nuran
dc.contributor.authorCikrikcili, Ugur
dc.contributor.authorNoyan, Handan
dc.contributor.authorYokusoglu, Cagdas
dc.contributor.authorDevrim-Ucok, Muge
dc.date.accessioned2020-09-25T07:46:54Z
dc.date.available2020-09-25T07:46:54Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, İnsan ve Toplum Bilimleri Fakültesi, Psikoloji Bölümüen_US
dc.description.abstractAim: Negative symptoms and cognition are related with functioning in schizophrenia. However, it is not clear whether they have a similar effect in individuals at ultra-high risk (UHR) for psychosis. In this study, we aimed to explore relationship of negative symptoms with cognition and functioning cross-sectionally in people with UHR for psychosis. Methods: In total, 107 people participated in this study. We assessed negative symptoms with Scale for Negative Symptoms (SANS). We applied a cognitive battery including seven tests. We evaluated functioning by using Global Assessment of Functioning Scale and work/study status as an indicator of role functioning. Results: SANS scores were correlated to global functioning cross-sectionally. SANS total score was correlated to cognitive test scores related to cognitive flexibility and attention. Only Trail Making Test B (TMT B) was negatively correlated to global functioning. SANS-affective blunting and SANS-avolition scores were independently related to global functioning. There was a significant indirect effect of the TMT B and composite attention scores on global functioning through negative symptoms indicating a complete mediation. Conclusion: Our findings suggest that negative symptoms, particularly avolition have an impact on functioning and the association of cognition with functioning was mediated by negative symptoms in UHR. © 2020 John Wiley & Sons Australia, Ltden_US
dc.identifier.citationÜçok, A., Direk, N., Kaya, H., Çağlar, N., Çıkrıkçılı, U., Noyan, H., ... & Devrim‐Üçok, M. (2016). Relationship of negative symptom severity with cognitive symptoms and functioning in subjects at ultra‐high risk for psychosis. Early Intervention in Psychiatry.en_US
dc.identifier.doi10.1111/eip.13042en_US
dc.identifier.pmid32945138en_US
dc.identifier.scopus2-s2.0-85090998309en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1111/eip.13042
dc.identifier.uri17517885
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1103
dc.identifier.wosWOS:000570144400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorNoyan, Handan
dc.language.isoenen_US
dc.publisherBlackwell Publishingen_US
dc.relation.ispartofEarly Intervention in Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCognitionen_US
dc.subjectFunctioningen_US
dc.subjectNegative Symptomsen_US
dc.subjectUltra-High Risk For Psychosisen_US
dc.titleRelationship of negative symptom severity with cognitive symptoms and functioning in subjects at ultra-high risk for psychosisen_US
dc.typeArticleen_US

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