Multi-organs-on-chips for testing small-molecule drugs: challenges and perspectives

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dc.authoridBerivan Çeçen / 0000-0002-0081-2004en_US
dc.authorscopusidBerivan Çeçen / 24461480700en_US
dc.authorwosidBerivan Çeçen / Q-4203-2019
dc.contributor.authorÇeçen, Berivan
dc.contributor.authorKaravasili, Christina
dc.contributor.authorNazir, Mubashir
dc.contributor.authorBhusal, Anant
dc.contributor.authorDoğan, Elvan
dc.date.accessioned2021-10-28T07:23:39Z
dc.date.available2021-10-28T07:23:39Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Moleküler Biyoloji ve Genetik Bölümüen_US
dc.description.abstractOrgan-on-a-chip technology has been used in testing small-molecule drugs for screening potential therapeutics and regulatory protocols. The technology is expected to boost the development of novel therapies and accelerate the discovery of drug combinations in the coming years. This has led to the development of multi-organ-on-a-chip (MOC) for recapitulating various organs involved in the drug–body interactions. In this review, we discuss the current MOCs used in screening small-molecule drugs and then focus on the dynamic process of drug absorption, distribution, metabolism, and excretion. We also address appropriate materials used for MOCs at low cost and scale-up capacity suitable for high-performance analysis of drugs and commercial high-throughput screening platforms. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.en_US
dc.identifier.citationBerivan Cecen, Christina Karavasili, Mubashir Nazir, Anant Bhusal, Elvan Dogan, Fatemeh Shahriyari, Sedef Tamburaci, Melda Buyukoz, Leyla Didem Kozaci, & Amir K. Miri. (2021). Multi-Organs-on-Chips for Testing Small-Molecule Drugs: Challenges and Perspectives. Pharmaceutics, 13(1657), 1657. https://doi.org/10.3390/pharmaceutics13101657en_US
dc.identifier.doi10.3390/pharmaceutics13101657en_US
dc.identifier.endpage21en_US
dc.identifier.issn1999-4923en_US
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-85117517588en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics13101657
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2194
dc.identifier.volume13en_US
dc.identifier.wosWOS:000714080800001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÇeçen, Berivan
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofPharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-throughput Screeningen_US
dc.subjectMicrofluidicsen_US
dc.subjectMulti-organ-on-a-chipen_US
dc.subjectSmall Drugsen_US
dc.titleMulti-organs-on-chips for testing small-molecule drugs: challenges and perspectivesen_US
dc.typeArticleen_US

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