Pharmacogenetic aspect of intravitreal ranibizumab treatment in neovascular age-related macular degeneration: a five-year follow-up
Yükleniyor...
Dosyalar
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: This study aims to evaluate the role of complement factor H (CFH) in response to intravitreal ranibizumab (IVR) treatment, which is administered to patients with neovascular age-related macular degeneration (nAMD).Methods: In this retrospective study, 90 nAMD patients' 90 eyes were evaluated. IVR was injected once a month for three consecutive months, and then, patients were followed up for five years by using pro re nata method.Results: Average visual acuity (BCVA) values in TT group for the third, fourth and fifth years were found to be significantly higher than those in TC and CC groups, while average BCVA values in TC group were significantly higher than those in CC group (all p = .000 < .0167).Conclusion: Patients with CFH TT genotype responded significantly better to treatment after third year, while patients with CC genotype had a poorer response to IVR.
Açıklama
Anahtar Kelimeler
Age-Related Macular Degeneration, Complement Factor H Polymorphism, Genetics, Inflammation, Intravitreal Ranibizumab
Kaynak
Ocular Immunology and Inflammation
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
26
Sayı
6
Künye
Sengul, E. A., Artunay, O., Rasier, R., Kockar, A., Afacan, C., Hancer, V. S., & Yuzbasioglu, E. (2018). Pharmacogenetic aspect of intravitreal ranibizumab treatment in neovascular age-related macular degeneration: a five-year follow-up. Ocular immunology and inflammation, 26(6), 971-977.
