The protective effect of carvacrol on bevacizumab-related skin injury in rats: a biochemical and histopathological evaluation

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dc.authoridDamla Demir / 0000-0001-9637-0206
dc.authorscopusidDamla Demir / 57913385800en_US
dc.authorwosidDamla Demir / DVC-4108-2022en_US
dc.contributor.authorGöre Karaali, Müge
dc.contributor.authorKaraali, Soner
dc.contributor.authorDemir, Damla
dc.contributor.authorYazıcı, Gülce Naz
dc.contributor.authorÇoban, Abdülkadir
dc.contributor.authorMammadov, Renad
dc.contributor.authorSüleyman, Bahadır
dc.contributor.authorSüleyman, Halis
dc.date.accessioned2022-11-08T13:10:56Z
dc.date.available2022-11-08T13:10:56Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.description.abstractPurpose: Bevacizumab is a recombinant humanized monoclonal antibody that specifically binds to vascular endothelial growth factor (VEGF). Cutaneous side effects of bevacizumab are seen with substantial frequency and may require the interruption of the treatment. The aim of the study was to conduct a biochemical and histopathological investigation of the effects of carvacrol against the possible oxidative skin damage caused by bevacizumab in rats. Materials and methods: A total of 18 adult male Wistar albino rats were randomly assigned to three groups as healthy (H group; n = 6), bevacizumab alone (B group; n = 6), and carvacrol + bevacizumab (CB group; n = 6). Carvacrol was injected intraperitoneally (IP) at a dose of 50 mg/kg in the CB group. Sterile salt solution (0.9% NaCl) was used as a solvent for the H and B groups. One hour after the administration of carvacrol and solvent, bevacizumab at a dose of 10 mg/kg IP was administered to the CB and B groups. Bevacizumab was given once daily for a total of two doses, 15 days apart. Carvacrol was administered once daily for one month. After that period, all animals were sacrificed and their skin tissues removed. Malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPO), catalase (CAT), superoxide dismutase (SOD), total oxidant status (TOS), and total antioxidant status (TAS) levels in rats’ skin tissues were biochemically evaluated. The parameters were measured with spectrophotometric method by using a microplate reader (BioTek, Winooski, VT, USA). The skin tissues were also examined histopathologically by the pathologist (blind) for the study groups. Results: The MDA and TOS levels of the H and CB groups were significantly lower than the B group (p < 0.05). The mean scores of the other biochemical levels (GSH, GPO, CAT, SOD, TAS) in the H group were significantly higher than in the B and CB groups. Pathological examination of H group was normal. In B group epidermal atrophy, abnormal keratin accumulation, degenerated hair follicles, edoema and inflammatory cells accumulation in the dermis were observed. In the CB group, these findings were significantly improved. Conclusion: The positive effect of carvacrol against possible local oxidative skin damage due to bevacizumab in rats was demonstrated. In addition, more detailed studies are required to clarify the mechanism of the protective effect of carvacrol against bevacizumab-induced skin toxicity. The effect should be evaluated through further human studies, as well as studies using different doses of carvacrol.en_US
dc.identifier.citationGore Karaali, M., Karaali, S., Demir, D., Yazıcı, G. N., Coban, A., Mammadov, R., . . . Suleyman, H. (2022). The protective effect of carvacrol on bevacizumab-related skin injury in rats: A biochemical and histopathological evaluation. Cutaneous and Ocular Toxicology, doi:10.1080/15569527.2022.2124413en_US
dc.identifier.doi10.1080/15569527.2022.2124413en_US
dc.identifier.scopus2-s2.0-85139143492en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1080/15569527.2022.2124413
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3255
dc.identifier.wosWOS:000857403600001en_US
dc.identifier.wosqualityQ3 - Q4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDemir, Damla
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofCutaneous and Ocular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBevacizumaben_US
dc.subjectCarvacrolen_US
dc.subjectOxidative Stressen_US
dc.subjectRaten_US
dc.subjectSkin Toxicityen_US
dc.titleThe protective effect of carvacrol on bevacizumab-related skin injury in rats: a biochemical and histopathological evaluationen_US
dc.typeArticleen_US

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