Silver nanoparticle/capecitabine for breast cancer cell treatment
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
This study aimed to evaluate antiproliferative and proapoptotic effects of Capecitabine bonded silver particles on human breast cancer cells (MCF-7). Different sizes of Ag NPs (in sizes 5, 10, 15, 30 nm) were synthesized. The characterization of silver and drug-bonded silver nanoparticles was performed through UV-VIS, FTIR, and SEM analysis. Silver and drug-bonded silver nanoparticles were measured by zetasizer. Antiproliferative and proapoptotic effects of capecitabine, silver and drug-bonded silver nanoparticles were evaluated using XTT, Anneksin V, respectively. According to the results, silver nanoparticles of 10 nm size have shown the lowest toxic effect. Drug-bonded nanoparticles significantly increased the number of early and late apoptotic cells on MCF-7 cells.
Açıklama
Anahtar Kelimeler
Breast Cancer (Mcf-7), Capecitabine, Silver Nanoparticles, Apoptosis
Kaynak
Toxicology In Vitro
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
61
Sayı
Künye
Hepokur, C., Kariper, I. A., Misir, S., Ay, E., Tunoglu, S., Ersez, M. S., … Yaylim, I. (2019). Silver nanoparticle/capecitabine for breast cancer cell treatment. TOXICOLOGY IN VITRO, 61. https://doi.org/10.1016/j.tiv.2019.104600
