Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches

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dc.authoridAli Zarrabi / 0000-0003-0391-1769en_US
dc.authorscopusidAli Zarrabi / 23483174100
dc.authorwosidAli Zarrabi / U-2602-2019en_US
dc.contributor.authorAshrafizadeh, Milad
dc.contributor.authorDelfi, Masoud
dc.contributor.authorZarrabi, Ali
dc.contributor.authorSharifi, Esmaeel
dc.contributor.authorRabiee, Navid
dc.contributor.authorPaiva-Santos, Ana Cláudia
dc.contributor.authorKumar, Alan Prem
dc.contributor.authorHushmandi, Kiavash
dc.contributor.authorNazarzadeh Zare, Ehsan
dc.contributor.authorMakvandi, Pooyan
dc.date.accessioned2022-08-10T13:41:22Z
dc.date.available2022-08-10T13:41:22Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Mühendislik ve Doğa Bilimleri Fakültesi, Biyomedikal Mühendisliği Bölümüen_US
dc.description.abstractThe site-specific delivery of antitumor agents is of importance for providing effective cancer suppression. Poor bioavailability of anticancer compounds and the presence of biological barriers prevent their accumulation in tumor sites. These obstacles can be overcome using liposomal nanostructures. The challenges in cancer chemotherapy and stimuli-responsive nanocarriers are first described in the current review. Then, stimuli-responsive liposomes including pH-, redox-, enzyme-, light-, thermo- and magneto-sensitive nanoparticles are discussed and their potential for delivery of anticancer drugs is emphasized. The pH- or redox-sensitive liposomes are based on internal stimulus and release drug in response to a mildly acidic pH and GSH, respectively. The pH-sensitive liposomes can mediate endosomal escape via proton sponge. The multifunctional liposomes responsive to both redox and pH have more capacity in drug release at tumor site compared to pH- or redox-sensitive alone. The magnetic field and NIR irradiation can be exploited for external stimulation of liposomes. The light-responsive liposomes release drugs when they are exposed to irradiation; thermosensitive-liposomes release drugs at a temperature of >40 °C when there is hyperthermia; magneto-responsive liposomes release drugs in presence of magnetic field. These smart nanoliposomes also mediate co-delivery of drugs and genes in synergistic cancer therapy. Due to lack of long-term toxicity of liposomes, they can be utilized in near future for treatment of cancer patients.en_US
dc.identifier.citationAshrafizadeh M, Delfi M, Zarrabi A, Bigham A, Sharifi E, Rabiee N, Paiva-Santos AC, Kumar AP, Tan SC, Hushmandi K, Ren J, Zare EN, Makvandi P. Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches. J Control Release. 2022 Aug 4:S0168-3659(22)00481-3. doi: 10.1016/j.jconrel.2022.08.001. Epub ahead of print. PMID: 35934254.en_US
dc.identifier.doi10.1016/j.jconrel.2022.08.001en_US
dc.identifier.issn0168-3659en_US
dc.identifier.pmid35934254en_US
dc.identifier.scopus2-s2.0-85138166085en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3082
dc.identifier.wosWOS:000862830400001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZarrabi, Ali
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Controlled Releaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdvanced Nanostructuresen_US
dc.subjectCancer Therapyen_US
dc.subjectDrug Resistanceen_US
dc.subjectLiposomesen_US
dc.subjectTargeted Deliveryen_US
dc.titleStimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approachesen_US
dc.typeArticleen_US

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