Comparison of bone marrow biopsy and fluorodeoxyglucose-positron emission tomography for the assessment of bone marrow infiltration in children with Hodgkin's lymphoma

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dc.authoridOzdemir, Gul Nihal/0000-0002-3204-4353
dc.authorwosidARSLANTAS, ESRA/IZQ-5302-2023
dc.authorwosidOzdemir, Gul Nihal/AAO-9962-2020
dc.contributor.authorArslantas, Esra
dc.contributor.authorAycicek, Ali
dc.contributor.authorAkici, Ferhan
dc.contributor.authorOzkara, Selvinaz
dc.contributor.authorYilmaz, Burcak
dc.contributor.authorOzdemir, Nihal
dc.contributor.authorBayram, Cengiz
dc.date.accessioned2024-05-19T14:42:28Z
dc.date.available2024-05-19T14:42:28Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractPurpose To compare bone marrow biopsy (BMB) with [18F]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (PET/CT) imaging in the demonstration of bone marrow involvement in children with Hodgkin's Lymphoma (HL) and to investigate the effectiveness of PET/CT imaging and thus the necessity for BMB at staging.Methods Pediatric patients with HL, who underwent both bilateral iliac BMB and PET/CT imaging at disease staging were retrospectively analyzed. In determining bone marrow involvement (BMinv), BMB and/or first/follow-up PET/CT imaging were eligible for review.Results Fifty-six patients were included. BMinv was detected by PET/CT imaging in 6/56 (10.7%), whereas the proportion was 3/56 (5.3%) in BMB specimens. Bone marrow biopsies and PET/CT images were concordant in 53/56 (94.6%) patients with BMB specimens missing three cases of BMinv detected by PET/CT. When diagnostic accuracy was calculated, sensitivity, specificity, positive predictive value and negative predictive values for PET/CT were 100%, 100%, 100%, 100%, respectively, and the same values for BMB were 50%, 100%, 100%, 94.3%, respectively.Conclusions The results of PET/CT and BMB for staging of pediatric HL patients were compatible, and PET/CT imaging was found to provide high diagnostic performance in determining BMinv. In keeping with earlier research, the current study showed that BMB may not be necessary in every patient at staging, and should be reserved for cases where PET/CT is inconclusive.en_US
dc.identifier.doi10.1055/a-1972-9292
dc.identifier.endpage26en_US
dc.identifier.issn0029-5566
dc.identifier.issn2567-6407
dc.identifier.issue1en_US
dc.identifier.pmid36746148en_US
dc.identifier.scopus2-s2.0-85147460979en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage20en_US
dc.identifier.urihttps://doi.org10.1055/a-1972-9292
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5245
dc.identifier.volume62en_US
dc.identifier.wosWOS:000927006000002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofNuklearmedizin-Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectHodgkin's Lymphomaen_US
dc.subjectPositron Emission Tomographyen_US
dc.subjectBone Marrow Biopsyen_US
dc.subjectLymphoma Stagingen_US
dc.subjectChilden_US
dc.titleComparison of bone marrow biopsy and fluorodeoxyglucose-positron emission tomography for the assessment of bone marrow infiltration in children with Hodgkin's lymphomaen_US
dc.typeArticleen_US

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