Determination of phenytoin at trace levels in domestic wastewater and synthetic urine samples by gas chromatography-mass spectrometry after its preconcentration by simple liquid-phase microextraction

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dc.authoridBodur, Süleyman/0000-0002-2994-9047
dc.authorwosidBodur, Süleyman/AHB-4581-2022
dc.contributor.authorBodur, Sezin Erarpat
dc.contributor.authorAyan, Gizem Nur
dc.contributor.authorBodur, Suleyman
dc.contributor.authorGunkara, Omer Tahir
dc.contributor.authorBakirdere, Sezgin
dc.date.accessioned2024-05-19T14:46:12Z
dc.date.available2024-05-19T14:46:12Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractThis work presents a sensitive and accurate analytical method for the determination of phenytoin at trace levels in domestic wastewater and synthetic urine samples by gas chromatography-mass spectrometry (GC-MS) after the metal sieve-linked double syringe liquid-phase microextraction (MSLDS-LPME) method. A metal sieve was produced in our laboratory in order to disperse water-immiscible extraction solvents into aqueous media. Univariate optimization studies for the selection of proper extraction solvent, extraction solvent volume, mixing cycle, and initial sample volume were carried out. Under the optimum MSLDS-LPME conditions, mass-based dynamic range, limit of quantitation (LOQ), limit of detection (LOD), and percent relative standard deviation (%RSD) for the lowest concentration in calibration plot were figured out to be 100.5-10964.2 mu g kg-1, 150.6 mu g kg-1, 45.2 mu g kg-1, and 9.4%, respectively. Detection power was improved as 187.7-folds by the developed MSLDS-LPME-GC-MS system while enhancement in calibration sensitivity was recorded as 188.0-folds. In the final step of this study, the accuracy and applicability of the proposed system were tested by matrix matching calibration strategy. Percent recovery results for domestic wastewater and synthetic urine samples were calculated as 95.6-110.3% and 91.7-106.6%, respectively. These results proved the accuracy and applicability of the proposed preconcentration method, and the obtained analytical results showed the efficiency of the lab-made metal sieve apparatus.en_US
dc.description.sponsorshipYildiz Technical University Scientific Research Project [FYL-2022-4855]en_US
dc.description.sponsorshipThis work was funded by Yildiz Technical University Scientific Research Project with the project number FYL-2022-4855.en_US
dc.identifier.doi10.1007/s10661-024-12544-y
dc.identifier.issn0167-6369
dc.identifier.issn1573-2959
dc.identifier.issue5en_US
dc.identifier.pmid38622372en_US
dc.identifier.scopus2-s2.0-85190429333en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org10.1007/s10661-024-12544-y
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5468
dc.identifier.volume196en_US
dc.identifier.wosWOS:001204732500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEnvironmental Monitoring and Assessmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectPhenytoinen_US
dc.subjectMetal Sieve-Linked Double Syringe Liquid-Phase Microextractionen_US
dc.subjectGas Chromatography-Mass Spectrometryen_US
dc.subjectDomestic Wastewateren_US
dc.subjectUrineen_US
dc.titleDetermination of phenytoin at trace levels in domestic wastewater and synthetic urine samples by gas chromatography-mass spectrometry after its preconcentration by simple liquid-phase microextractionen_US
dc.typeArticleen_US

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