Advancements and applications of upconversion nanoparticles in wound dressings

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dc.authoridYaşayan, Gökçen/0000-0002-5299-2924
dc.authoridZarrabi, Ali/0000-0003-0391-1769
dc.authoridIravani, Siavash/0000-0003-3985-7928
dc.authoridBAL OZTURK, AYCA/0000-0002-6502-528X
dc.authoridSimchi, Abdolreza/0000-0002-9111-2977
dc.authoridGULTEKIN, HAZAL EZGI/0000-0001-6438-8006
dc.authorwosidYaşayan, Gökçen/E-4506-2013
dc.authorwosidZarrabi, Ali/U-2602-2019
dc.authorwosidIravani, Siavash/F-4046-2014
dc.authorwosidBAL OZTURK, AYCA/M-4472-2018
dc.contributor.authorGultekin, Hazal Ezgi
dc.contributor.authorYasayan, Gokcen
dc.contributor.authorBal-Ozurk, Ayca
dc.contributor.authorBigham, Ashkan
dc.contributor.authorSimchi, Abdolreza (Arash)
dc.contributor.authorZarepour, Atefeh
dc.contributor.authorIravani, Siavash
dc.date.accessioned2024-05-19T14:50:38Z
dc.date.available2024-05-19T14:50:38Z
dc.date.issued2024
dc.departmentİstinye Üniversitesien_US
dc.description.abstractWound healing is a complex process that requires effective management to prevent infections and promote efficient tissue regeneration. In recent years, upconversion nanoparticles (UCNPs) have emerged as promising materials for wound dressing applications due to their unique optical properties and potential therapeutic functionalities. These nanoparticles possess enhanced antibacterial properties when functionalized with antibacterial agents, helping to prevent infections, a common complication in wound healing. They can serve as carriers for controlled drug delivery, enabling targeted release of therapeutic agents to the wound site, allowing for tailored treatment and optimal healing conditions. These nanoparticles possess the ability to convert near-infrared (NIR) light into the visible and/or ultraviolet (UV) regions, making them suitable for therapeutic (photothermal therapy and photodynamic therapy) and diagnostic applications. In the context of wound healing, these nanoparticles can be combined with other materials such as hydrogels, fibers, metal-organic frameworks (MOFs), graphene oxide, etc., to enhance the healing process and prevent the growth of microbial infections. Notably, UCNPs can act as sensors for real-time monitoring of the wound healing progress, providing valuable feedback to healthcare professionals. Despite their potential, the use of UCNPs in wound dressing applications faces several challenges. Ensuring the stability and biocompatibility of UCNPs under physiological conditions is crucial for their effective integration into dressings. Comprehensive safety and efficacy evaluations are necessary to understand potential risks and optimize UCNP-based dressings. Scalability and cost-effectiveness of UCNP synthesis and manufacturing processes are important considerations for practical applications. In addition, efficient incorporation of UCNPs into dressings, achieving uniform distribution, poses an important challenge that needs to be addressed. Future research should prioritize addressing concerns regarding stability and biocompatibility, efficient integration into dressings, rigorous safety evaluation, scalability, and cost-effectiveness. The purpose of this review is to critically evaluate the advantages, challenges, and key properties of UCNPs in wound dressing applications to provide insights into their potential as innovative solutions for enhancing wound healing outcomes. We have provided a detailed description of various types of smart wound dressings, focusing on the synthesis and biomedical applications of UCNPs, specifically their utilization in different types of wound dressings. In this review, we aim to showcase the potential and benefits of up-conversion nanoparticles (UCNPs) in advanced wound care applications.en_US
dc.identifier.doi10.1039/d3mh01330h
dc.identifier.endpage387en_US
dc.identifier.issn2051-6347
dc.identifier.issn2051-6355
dc.identifier.issue2en_US
dc.identifier.pmid37955196en_US
dc.identifier.scopus2-s2.0-85176947302en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://doi.org10.1039/d3mh01330h
dc.identifier.urihttps://hdl.handle.net/20.500.12713/5763
dc.identifier.volume11en_US
dc.identifier.wosWOS:001101051900001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofMaterials Horizonsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectMetal-Organic Frameworksen_US
dc.subjectUpconverting Nanoparticlesen_US
dc.subjectDrug-Deliveryen_US
dc.subjectInjectable Hydrogelsen_US
dc.subjectTherapyen_US
dc.subjectAntibacterialen_US
dc.subjectSirnaen_US
dc.subjectPhen_US
dc.titleAdvancements and applications of upconversion nanoparticles in wound dressingsen_US
dc.typeReview Articleen_US

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