Association between ? arrestin 2 and filamin A gene variations with medical treatment response in acromegaly patients

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dc.authoridNurperi Gazioğlu / 0000-0001-7785-8628en_US
dc.authorscopusidNurperi Gazioğlu / 6601973313
dc.authorwosidNurperi Gazioğlu / AAJ-3648-2021
dc.contributor.authorAkdemir, Ayşe S.
dc.contributor.authorMetin Armağan, Derya
dc.contributor.authorPolat Korkmaz, Özge
dc.contributor.authorÖzkaya, Hande M.
dc.contributor.authorKadıoğlu, Pınar
dc.contributor.authorGazioğlu, Nurperi
dc.date.accessioned2021-10-27T07:50:32Z
dc.date.available2021-10-27T07:50:32Z
dc.date.issued2021en_US
dc.departmentİstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.description.abstractBackground: Acromegaly is a disease that occurs as a result of excessive growth hormone caused by pituitary adenomas. Some acromegaly patients show resistance to somatostatin analog (SSA) treatment. Filamin-A (FLNA) and ?-arrestins are thought to play a role in the response to SSAs. We aimed to investigate the relationship between FLNA-rs782079491 and ?-arrestin-2-rs34230287 single-nucleotide polymorphisms and disease risk, as well as treatment response in patients with acromegaly in the Turkish population. Methods: The genotypes of 110 acromegaly patients and 99 controls were determined by realtime PCR. The genotype distributions were compared with clinical data on the disease. Results: There was no association between the ?-arrestin-2 gene polymorphism and the response to SSA treatment in acromegaly patients. For responder patients to SSAs, the ?-arrestin-2-rs34230287 CT+TT genotype was associated with higher microadenoma as compared with the CC genotype (p = 0.017). The FLNA polymorphism was not observed in the study group. Conclusions: We showed that there was no association between the polymorphic genotypes of FLNA and ?-arrestin-2 genes with acromegaly disease and SSAs response in the Turkish population. However, there was a relationship between ?-arrestin-2 and some of the clinical characteristics. Furthermore, the CC genotype and the C allele are risk factors associated with tumor growth rate in acromegaly patients.en_US
dc.identifier.citationAkdemir, A. S., Metin Armagan, D., Polat Korkmaz, O., Ozkaya, H. M., Kadioglu, P., Gazioglu, N., Tanriover, N., Dirican, A., & Ozturk, M. (2021). Association between β arrestin 2 and filamin A gene variations with medical treatment response in acromegaly patients. Minerva endocrinology, 10.23736/S2724-6507.21.03611-3. Advance online publication.en_US
dc.identifier.doi10.23736/S2724-6507.21.03611-3en_US
dc.identifier.pmid34669321en_US
dc.identifier.urihttps://doi.org/10.23736/S2724-6507.21.03611-3
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2191
dc.identifier.wosWOS:001162917400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorGazioğlu, Nurperi
dc.language.isoenen_US
dc.publisherEDIZIONI MINERVA MEDICAen_US
dc.relation.ispartofMinerva Endocrinol (Torino) .en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleAssociation between ? arrestin 2 and filamin A gene variations with medical treatment response in acromegaly patientsen_US
dc.typeArticleen_US

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