Nephrolithiasis during the first 6 months of life in exclusively breastfed infants

Basit Öğe Kaydı
dc.authorscopusidAli Koçyiğit / 36196864600
dc.contributor.authorYılmaz, Neslihan
dc.contributor.authorYuksel, Selcuk
dc.contributor.authorAltindas, Fatih
dc.contributor.authorKoçyiğit, Ali
dc.date.accessioned2020-11-09T07:46:33Z
dc.date.available2020-11-09T07:46:33Z
dc.date.issued2020en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractBackground: We investigated etiology and prognosis of infantile nephrolithiasis, including whether lithogenic and anti-lithogenic content of breast milk affects its formation. Methods: Thirty infants with nephrolithiasis and 30 healthy infants exclusively breastfed for the first 6 months of life were included in this prospective cohort case-control study. At entry, age, sex, and timing of birth of patients and controls were recorded. All patients were diagnosed and followed up periodically using ultrasonography. All infants received oral vitamin D (400 units/day). Lithogenic (calcium, oxalate, uric acid, phosphate) and anti-lithogenic (citrate, magnesium) components of maternal milk, serum calcium, phosphate, magnesium, 25-hydroxy vitamin D and parathormone, as well as spot urine calcium, uric acid, cystine, oxalate, magnesium, citrate/creatinine ratio, and calcium/citrate ratio were compared. Results: Mean follow-up period was 56.1 ± 6.8 months. There was no difference concerning lithogenic and anti-lithogenic content of breast milk. Serum calcium, phosphorus, alkaline phosphatase, and 25-hydroxy vitamin D levels (49.1 ± 19 vs. 26.7 ± 4 ng/ml, p < 0.001) were significantly higher and parathormone level significantly lower in patients. Random urine calcium/creatinine and calcium/citrate ratios were significantly higher in patient group (0.63 ± 0.40 vs. 0.42 ± 0.10 and 0.62 ± 0.12 vs. 0.41 ± 0.25 mg/mg, respectively, p < 0.01). Three patients were lost to follow-up after the first year. At last follow-up, calculi disappeared in 25/27 remaining patients without interventions or therapy. Conclusions: Breast milk does not have an etiologic effect in infantile nephrolithiasis. Higher serum vitamin D levels may have roles in development of lower levels of PTH and higher levels of serum and urine calcium, leading to stone formation. The prognosis for infantile stones is excellent. Graphical abstract.en_US
dc.identifier.citationYılmaz, N., Yüksel, S., Altıntaş, F., & Koçyiğit, A. (2020). Nephrolithiasis during the first 6 months of life in exclusively breastfed infants. Pediatric nephrology (Berlin, Germany), 10.1007/s00467-020-04815-w. Advance online publication. https://doi.org/10.1007/s00467-020-04815-wen_US
dc.identifier.doi10.1007/s00467-020-04815-wen_US
dc.identifier.pmid33150500en_US
dc.identifier.scopus2-s2.0-85095459794en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.1007/s00467-020-04815-w
dc.identifier.urihttps://hdl.handle.net/20.500.12713/1185
dc.identifier.wosWOS:000585717700001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorKoçyiğit, Ali
dc.language.isoenen_US
dc.relation.ispartofPediatric nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreastmilk Contenen_US
dc.subjectCalculien_US
dc.subjectHypercalciuriaen_US
dc.subjectInfantsen_US
dc.subjectVitamin Den_US
dc.titleNephrolithiasis during the first 6 months of life in exclusively breastfed infantsen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
Yılmaz2020_Article_NephrolithiasisDuringTheFirst6.pdf
Boyut:
216.46 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

PubMed İndeksli Yayınlar Koleksiyonu
İSÜ Hastaneleri Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu