Development and characterization of bilayered tablets of diazepam for oral drug delivery: design, optimization and in vitro evaluation

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dc.authorwosidHamit Cilvegar / CLN-4514-2022
dc.contributor.authorSalatin, Sara
dc.contributor.authorAlami-Milani, Mitra
dc.contributor.authorCilvegar, Hamit
dc.contributor.authorFereidouni, Saber
dc.contributor.authorMonajemzadeh, Farnaz
dc.contributor.authorJelvehgari, Mitra
dc.date.accessioned2022-03-24T08:16:18Z
dc.date.available2022-03-24T08:16:18Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.description.abstractAims: The oral bioavailability of drugs can be limited by their short residence time in the gastrointestinal tract. This study was performed to design bilayered floating tablets of diazepam comprising immediate-release and controlled-release layers. Methods: The tablets were prepared using sodium starch glycolate, polyvinyl pyrrolidone, hydroxypropyl methylcellulose and microcrystalline cellulose and evaluated for their characteristics. Results: The optimized formulation was found to be buoyant for 8 h on simulated gastric fluid. Hydroxypropyl methylcellulose K4M and microcrystalline cellulose sustained the release of diazepam from the controlled-release layer. The optimized formulation exhibited an extended release period of 8 h. Discussion/conclusion: It can be concluded that bilayered tablets of diazepam may extend the residence time of the drug at the site of absorption.en_US
dc.identifier.citationSalatin S, Alami-Milani M, Cilvegar H, Fereidouni S, Maghsoodi M, Monajemzadeh F, Jelvehgari M. Development and characterization of bilayered tablets of diazepam for oral drug delivery: design, optimization and in vitro evaluation. Ther Deliv. 2022 Mar 21.en_US
dc.identifier.doi10.4155/tde-2021-0077en_US
dc.identifier.pmid35306880en_US
dc.identifier.scopus2-s2.0-85131219736en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.urihttps://doi.org/10.4155/tde-2021-0077
dc.identifier.urihttps://hdl.handle.net/20.500.12713/2584
dc.identifier.wosWOS:000771718200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCilvegar, Hamit
dc.language.isoenen_US
dc.relation.ispartofTher Deliven_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHPMCen_US
dc.subjectBilayered Tableten_US
dc.subjectDiazepamen_US
dc.subjectFloatingen_US
dc.subjectGastrointestinal Tracten_US
dc.subjectOral Drug Deliveryen_US
dc.titleDevelopment and characterization of bilayered tablets of diazepam for oral drug delivery: design, optimization and in vitro evaluationen_US
dc.typeArticleen_US

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