Mildronate Has Ameliorative Effects on the Experimental Ischemia/Reperfusion Injury Model in the Rabbit Spinal Cord

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dc.authoridKuru Bektasoglu, Pinar/0000-0001-9889-9955
dc.authoridGurer, Bora/0000-0003-1500-6184
dc.authoridOzaydin, Dilan/0000-0002-1525-7613
dc.authorwosidKuru Bektasoglu, Pinar/K-8612-2013
dc.authorwosidGurer, Bora/K-1177-2012
dc.contributor.authorOzaydin, Dilan
dc.contributor.authorBektasoglu, Pinar Kuru
dc.contributor.authorTure, Durukan
dc.contributor.authorBozkurt, Huseyin
dc.contributor.authorErguder, Berrin Imge
dc.contributor.authorSargon, Mustafa Fevzi
dc.contributor.authorArikok, Ata Turker
dc.date.accessioned2024-05-19T14:39:02Z
dc.date.available2024-05-19T14:39:02Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstract-BACKGROUND: Mildronate is a useful anti-ischemic agent and has antiinflammatory, antioxidant, and neuro-protective activities. The aim of this study is to investigate the potential neuroprotective effects of mildronate in the experimental rabbit spinal cord ischemia/reperfusion injury (SCIRI) model. -METHODS: Rabbits were randomized into 5 groups of 8 animals as groups 1 (control), 2 (ischemia), 3 (vehicle), 4 (30 mg/kg methylprednisolone [MP]), and 5 (100 mg/kg mildr-onate). The control group underwent only laparotomy. The other groups have the spinal cord ischemia model by a 20-minute aortic occlusion just caudal to the renal artery. The malondialdehyde and catalase levels and caspase-3, myeloperoxidase, and xanthine oxidase activities were investigated. Neurologic, histopathologic, and ultrastruc-tural evaluations were also performed. -RESULTS: The serum and tissue myeloperoxidase, malondialdehyde, and caspase-3 values of the ischemia and vehicle groups were statistically significantly higher than those of the MP and mildronate groups (P < 0.001). Serum and tissue catalase values of the ischemia and vehicle groups were statistically significantly lower than those of the control, MP, and mildronate groups (P< 0.001). The histopathologic evaluation showed a statistically significantly lower score in the mildronate and MP groups than in the ischemia and vehicle groups (P < 0.001). The modified Tarlov scores of the ischemia and vehicle groups were statistically significantly lower than those of the control, MP, and mildronate groups (P < 0.001).CONCLUSIONS: This study presented the antiin-flammatory, antioxidant, antiapoptotic, and neuroprotective effects of mildronate on SCIRI. Future studies will elucidate its possible use in clinical settings in SCIRI.en_US
dc.identifier.doi10.1016/j.wneu.2023.02.139
dc.identifier.endpageE726en_US
dc.identifier.issn1878-8750
dc.identifier.issn1878-8769
dc.identifier.pmid36889637en_US
dc.identifier.scopus2-s2.0-85150811807en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE717en_US
dc.identifier.urihttps://doi.org10.1016/j.wneu.2023.02.139
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4683
dc.identifier.volume173en_US
dc.identifier.wosWOS:001005088000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofWorld Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240519_kaen_US
dc.subjectAntiapoptoticen_US
dc.subjectAntiinflammatoryen_US
dc.subjectAntioxidanten_US
dc.subjectIschemiaen_US
dc.subjectReperfusionen_US
dc.subjectMildronateen_US
dc.subjectNeuroprotectiveen_US
dc.titleMildronate Has Ameliorative Effects on the Experimental Ischemia/Reperfusion Injury Model in the Rabbit Spinal Corden_US
dc.typeArticleen_US

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