Does vitamin D affect diabetic neuropathic pain and balance?

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dc.authoridBekir Durmuş / 0000-0001-6248-8476en_US
dc.authorscopusidBekir Durmuş / 35224662900
dc.authorwosidBekir Durmuş / ETW-3827-2022
dc.contributor.authorSarı, Aylin
dc.contributor.authorAltun, Zeynep Akdoğan
dc.contributor.authorKaraman, Ciğdem Arifoğlu
dc.contributor.authorKaya, Başak Bilir
dc.contributor.authorDurmuş, Bekir
dc.date.accessioned2020-08-30T20:06:22Z
dc.date.available2020-08-30T20:06:22Z
dc.date.issued2020
dc.departmentİstinye Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Bölümüen_US
dc.description.abstractPurpose: This randomized, placebo-controlled study examined the effect of vitamin D replacement therapy on neuropathic symptoms and balance in patients with diabetic neuropathic pain and low vitamin D levels. Patients and Methods: Among the 258 patients, the results in a total of 57 volunteers (32 in the treatment and 25 in the control arm) meeting the inclusion criteria are reported. Symptoms of neuropathic pain were assessed using Douleur Neuropathique 4 (DN4) questionnaire, and presence of polyneuropathy (PNP) was determined by performing electromyography (EMG). Balance was assessed using Berg balance test (BBT). After undergoing these examinations, the patients in the treatment group were intramuscularly (IM) injected with 300,000 IU vitamin D in a liquid formulation and those in the placebo group were IM injected with physiological saline. The DN4 and BBT were repeated after 12 weeks, and the results were compared. Results: The patients in the treatment group showed a significant decrease in total DN4 scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.008). The patients in the treatment group also showed a significant increase in BBT scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.001). Furthermore, in subgroup analysis, these patients showed a significant decrease in electric shock and burning sensation scores from baseline to the study endpoint compared with the patients in the placebo group (p=0.006, p=0.001, respectively). Conclusion: In patients with diabetic neuropathic pain, vitamin D levels should be measured and vitamin D replacement therapy should be administered as required to resolve neuropathic symptoms and to improve balance.en_US
dc.identifier.citationSari, A., Altun, Z. A., Karaman, C. A., Kaya, B. B., & Durmus, B. (2020). Does Vitamin D Affect Diabetic Neuropathic Pain and Balance?. Journal of Pain Research, 13, 171.en_US
dc.identifier.doi10.2147/JPR.S203176en_US
dc.identifier.endpage179en_US
dc.identifier.issn1178-7090en_US
dc.identifier.pmid32021406en_US
dc.identifier.scopus2-s2.0-85078336034en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage171en_US
dc.identifier.urihttps://doi.org/10.2147/JPR.S203176
dc.identifier.urihttps://hdl.handle.net/20.500.12713/492
dc.identifier.volume13en_US
dc.identifier.wosWOS:000510698400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDurmuş, Bekiren_US
dc.language.isoenen_US
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofJournal of Pain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiabetic Neuropathic Painen_US
dc.subjectVitamin Den_US
dc.subjectBalanceen_US
dc.subjectNeuropathic Pain Symptomsen_US
dc.titleDoes vitamin D affect diabetic neuropathic pain and balance?en_US
dc.typeArticleen_US

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