Degenerative changes of lumbar spine and their clinical implications in patients with axial spondyloarthritis

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dc.authoridSalih Özgöçmen / 0000-0002-4860-452Xen_US
dc.authorscopusidSalih Özgöçmen / 7003693574
dc.authorwosidSalih Özgöçmen / K-9588-2015en_US
dc.contributor.authorKılıç, Gamze
dc.contributor.authorŞenol, Serkan
dc.contributor.authorKılıç, Erkan
dc.contributor.authorÖzgöçmen, Salih
dc.date.accessioned2022-08-08T12:50:09Z
dc.date.available2022-08-08T12:50:09Z
dc.date.issued2022en_US
dc.departmentİstinye Üniversitesi, Hastaneen_US
dc.descriptionKey Points • Lumbar herniated nucleus pulposus (LHNP) is more frequent in nr-axSpA while MC is more frequent in AS. • DD may cause an increase in BASFI and BASMI scores in axSpA. • Spinal DCs might be an alternative explanation for low back complaints and should not been overlooked in patients with axSpAen_US
dc.description.abstractThe objective of this study was to assess degenerative changes (DCs) on magnetic resonance imaging (MRI) of lumbar spine in axial spondyloarthritis (axSpA) and non-specifc mechanical low back pain (mLBP). Patients were consecutively recruited and all underwent MRI of the lumbar spine in this cross-sectional study. Disk degeneration (DD, Pfrrmann classifcation), endplate changes (Modic, types 1, 2, and 3), annular fssure, disk bulging, and protrusion or extrusion at each lumbar spinal level were assessed using anonymized images. Patients with axSpA were assessed for disease activity, functioning, and quality of life. Univariate and subsequent multivariate logistic regression analyses with adjustments of various covariates were used to assess association between MRI fndings and clinical variables. One hundred twenty-three patients had non-radiographic (nr-axSpA) and 144 had radiographic axSpA/ankylosing spondylitis (AS). Degenerative changes were more prevalent in patients with mLBP (n=105) than axSpA. Disk degeneration was the most prevalent MRI fnding, followed by annular fssure, disk herniation (protrusion or extrusion), and Modic changes (MCs) in axSpA. Disk herniation was more prevalent in patients with nr-axSpA compared to AS. Modic changes (OR=6.455), lumbar disk herniation (OR=2.278), annular fssure (OR=2.842), conventional synthetic or biologic disease-modifying antirheumatic drugs (csDMARDs) non-users (OR=2.225), and advanced age (OR=31.556) were factors associated with an increased risk of DD in axSpA. Coexisting * Gamze Kilic gkilic.md@hotmail.com 1 Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Karadeniz Technical University, Trabzon, Turkey 2 Department of Radiology, Sevgi Hospital, Kayseri, Turkey 3 Department of Physical Medicine and Rehabilitation, Ministry of Health Kayseri City Hospital, Kayseri, Turkey 4 Department of Rheumatology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey 5 Department of Rheumatology, Gaziosmanpasa Hospital, Istinye University, Istanbul, Turkey 6 Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Trakya University, Edirne, Turkey DD increased the burden of disease in axSpA. A considerable proportion of patients with axSpA had DD at the lumbar spine. These degenerative changes might explain some of the complaints and should not been overlooked in patients with axSpA.en_US
dc.identifier.citationKilic G, Senol S, Baspinar S, Kilic E, Ozgocmen S. Degenerative changes of lumbar spine and their clinical implications in patients with axial spondyloarthritis. Clin Rheumatol. 2022 Aug 3. doi: 10.1007/s10067-022-06321-w. Epub ahead of print. PMID: 35922576.en_US
dc.identifier.doi10.1007/s10067-022-06321-wen_US
dc.identifier.issn0770-3198en_US
dc.identifier.pmid35922576en_US
dc.identifier.scopus2-s2.0-85135341792en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttp://doi.org/10.1007/s10067-022-06321-w
dc.identifier.urihttps://hdl.handle.net/20.500.12713/3075
dc.identifier.wosWOS:000835614600001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorÖzgöçmen, Salih
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofClinical Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing Spondylitisen_US
dc.subjectLow Back Painen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.titleDegenerative changes of lumbar spine and their clinical implications in patients with axial spondyloarthritisen_US
dc.typeArticleen_US

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