SARS-CoV-2 Causes Brain Damage: Therapeutic Intervention with AZD8797

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dc.authoridonen, engin alp/0000-0003-1661-5803
dc.authoridKÖROĞLU, AYÇA KARAGÖZ/0000-0002-2532-8091
dc.authoridSevic Yilmaz, Erva/0000-0002-0178-0112
dc.authorwosidKervancioglu Demirci, Elif/GQP-2823-2022
dc.authorwosidonen, engin alp/AAX-3151-2021
dc.authorwosidKÖROĞLU, AYÇA KARAGÖZ/AAL-9416-2020
dc.contributor.authorDemirci, Elif Kervancioglu
dc.contributor.authorOnen, Engin Alp
dc.contributor.authorYilmaz, Erva Sevic
dc.contributor.authorKoroglu, Ayca Karagoz
dc.contributor.authorAkakin, Dilek
dc.date.accessioned2024-05-19T14:40:32Z
dc.date.available2024-05-19T14:40:32Z
dc.date.issued2023
dc.departmentİstinye Üniversitesien_US
dc.description.abstractElevated CX3CL1 is associated with severe COVID-19 and neurologic symptoms. We aimed to investigate the potential protective effects of selective CX3CR1 antagonist AZD8797 on SARS-CoV-2-induced neuronal damage, and to identify the underlying mechanisms. K18-hACE2 transgenic mice (n = 37) were randomly divided into control groups and SARS-CoV-2 groups, with and without intraperitoneal administration of vehicle or AZD8797 (2.5 mg/mL/day), following exposure to either a single dose of SARS-CoV-2 inhalation or no exposure. Object recognition and hole board tests were performed to assess memory function. Postinfection 8 days, brain tissues were analyzed for histopathological changes, viral, glial, apoptotic, and other immunohistochemical markers, along with measuring malondialdehyde, glutathione, and myeloperoxidase activities. Serum samples were analyzed for proinflammatory cytokines. The SARS-CoV-2 group showed significant weight loss, neuronal damage, oxidative stress, and impaired object recognition memory, while AZD8797 treatment mitigated some of these effects, especially in weight, apoptosis, glutathione, and MCP-1. Histopathological analyses supported the protective effects of AZD8797 against SARS-CoV-2-induced damage. The CX3CL1-CX3CR1 signaling pathway could offer a promising target for reducing SARS-CoV-2's neurological impact, but additional research is needed to confirm these findings in combination with other therapies and assess the clinical significance.en_US
dc.description.sponsorshipWe thank Prof. Gulnaz Nural Bekiroglu of the Department of Biostatistics at Marmara School of Medicine for her statistical guidance, Dr. Turkan Koyuncuoglu of the Department of Physiology at Biruni University for her theoretical suggestions in behavioral ten_US
dc.description.sponsorshipWe thank Prof. Gulnaz Nural Bekiroglu of the Department of Biostatistics at Marmara School of Medicine for her statistical guidance, Dr. Turkan Koyuncuoglu of the Department of Physiology at Biruni University for her theoretical suggestions in behavioral tests, and DVM Ersun Bilecen for his assistance with animal care and behavioral tests.en_US
dc.identifier.doi10.1093/micmic/ozad129
dc.identifier.endpage2173en_US
dc.identifier.issn1431-9276
dc.identifier.issn1435-8115
dc.identifier.issue6en_US
dc.identifier.pmid37967299en_US
dc.identifier.scopus2-s2.0-85181177264en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2161en_US
dc.identifier.urihttps://doi.org10.1093/micmic/ozad129
dc.identifier.urihttps://hdl.handle.net/20.500.12713/4976
dc.identifier.volume29en_US
dc.identifier.wosWOS:001101855800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofMicroscopy and Microanalysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz20240519_kaen_US
dc.subjectCovid-19en_US
dc.subjectCx3cl1en_US
dc.subjectHistologyen_US
dc.subjectOxidative Stressen_US
dc.subjectTransgenic Miceen_US
dc.titleSARS-CoV-2 Causes Brain Damage: Therapeutic Intervention with AZD8797en_US
dc.typeArticleen_US

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