Anthelmintic activity of nigella sativa against caenorhabditis elegans
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Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
HORIZON RESEARCH PUBLISHING
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Increasing resistance against classical anthelmintic drugs makes discovering new anthelmintic compounds from natural plants important. Nigella sativa (N. sativa) is used as a medicinal plant overall the world and is known to have anthelmintic activity. Caenorhabditis elegans (C. elegans), a common cost-effective model organism that is easily maintained, is useful to determine the anthelmintic activity of new compounds derived from natural products. In our study we aimed to evaluate through toxicity assays the nematocidal activity of N. sativa on C. elegans during its larval and adult stages. Different concentrations of N. sativa oil (900, 450 and 270 mg/mL) were tested and toxicity assessments were done under stereomicroscope by counting the number of surviving nematodes. This study showed that N. sativa essential oil significantly decreases survival of C. elegans in both larval and adult stages at 900 mg/mL final concentration. Larval-stage worms were more sensitive to N. sativa essential oil than were adults. We recommend further studies on other effects of N. sativa on C. elegans after removing the toxic compound(s) from the extract. The further discovery of N. sativa essential oil compounds responsible for anthelmintic activity and determination of their mechanisms of toxicity can pave the way toward new medicines.
Açıklama
Anahtar Kelimeler
Nigella Sativa, Anthelmintic, Caenorhabditis Elegans, Medicinal Plants, Phytotherapy, Herbal Medicine
Kaynak
ADVANCES IN PHARMACOLOGY AND PHARMACY
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
9
Sayı
4
Künye
Yılmaz, M. (2019). Bibliyometriye Eleştirel Bir Bakış (A Critical View on Bibliometrics). Turk Kutuphaneciligi - Turkish Librarianship, 33(1), 43–49.
